Multiscale simulations of biological membranes: the challenge to understand biological phenomena in a living substance
Biological membranes are tricky to investigate. They are complex in terms of molecular
composition and structure, functional over a wide range of time scales, and characterized by …
composition and structure, functional over a wide range of time scales, and characterized by …
Dopamine receptors–IUPHAR R eview 13
JM Beaulieu, S Espinoza… - British journal of …, 2015 - Wiley Online Library
The variety of physiological functions controlled by dopamine in the brain and periphery is
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
mediated by the D 1, D 2, D 3, D 4 and D 5 dopamine GPCRs. Drugs acting on dopamine …
Molecular signatures of G-protein-coupled receptors
G-protein-coupled receptors (GPCRs) are physiologically important membrane proteins that
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …
sense signalling molecules such as hormones and neurotransmitters, and are the targets of …
G protein–coupled receptor oligomerization revisited: functional and pharmacological perspectives
Most evidence indicates that, as for family CG protein–coupled receptors (GPCRs), family A
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
GPCRs form homo-and heteromers. Homodimers seem to be a predominant species, with …
Action of molecular switches in GPCRs-theoretical and experimental studies
G protein coupled receptors (GPCRs), also called 7TM receptors, form a huge superfamily of
membrane proteins that, upon activation by extracellular agonists, pass the signal to the cell …
membrane proteins that, upon activation by extracellular agonists, pass the signal to the cell …
Conducting nanomaterial sensor using natural receptors
One of the recently emerging topics in biotechnology is natural receptors including G protein-
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …
coupled receptors, ligand-gated ion channels, enzyme-linked receptors, and intracellular …
Full characterization of GPCR monomer–dimer dynamic equilibrium by single molecule imaging
Receptor dimerization is important for many signaling pathways. However, the monomer–
dimer equilibrium has never been fully characterized for any receptor with a 2D equilibrium …
dimer equilibrium has never been fully characterized for any receptor with a 2D equilibrium …
[PDF][PDF] Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism
A Kern, R Albarran-Zeckler, HE Walsh, RG Smith - Neuron, 2012 - cell.com
We identified subsets of neurons in the brain that coexpress the dopamine receptor subtype-
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …
2 (DRD2) and the ghrelin receptor (GHSR1a). Combination of FRET confocal microscopy …
[HTML][HTML] Immunomodulatory effects of dopamine in inflammatory diseases
Y Feng, Y Lu - Frontiers in immunology, 2021 - frontiersin.org
Dopamine (DA) receptor, a significant G protein-coupled receptor, is classified into two
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …
families: D1-like (D1 and D5) and D2-like (D2, D3, and D4) receptor families, with further …
Crystal structure of oligomeric β1-adrenergic G protein–coupled receptors in ligand-free basal state
J Huang, S Chen, JJ Zhang, XY Huang - Nature structural & molecular …, 2013 - nature.com
G protein–coupled receptors (GPCRs) mediate transmembrane signaling. Before ligand
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …
binding, GPCRs exist in a basal state. Crystal structures of several GPCRs bound with …