A perplexing feature of type 1 diabetes (T1D) is that the immune system destroys pancreatic
β-cells but not neighbouring α-cells, even though both β-cells and α-cells are dysfunctional …

The p53 tumor suppressor protein is best known as an inhibitor of the cell cycle and an
inducer of apoptosis. Unexpectedly, these functions of p53 are not required for its tumor …

Microglia, the innate immune cells of the brain, influence Alzheimer's disease (AD)
progression and are potential therapeutic targets. However, microglia exhibit diverse …

Mycobacterium tuberculosis (Mtb) is known to evade host immune responses and persist in
macrophages for long periods. A mechanism that the host uses to combat Mtb is xenophagy …

TRIM proteins are the largest family of E3 ligases in mammals. They include the intracellular
antibody receptor TRIM21, which is responsible for mediating targeted protein degradation …

Rabies, a highly fatal zoonotic disease, is a significant global public health threat. Currently,
the pathogenic mechanism of rabies has not been fully elucidated, and no effective …

HIV-associated neurocognitive impairment (HIV-NCI) persists in 15-40% of people with HIV
(PWH) despite effective antiretroviral therapy. HIV-NCI significantly impacts quality of life …

Hepatitis E virus (HEV) is a long-neglected RNA virus and the major causative agent of
acute viral hepatitis in humans. Recent data suggest that HEV has a very heterogeneous …

The field of the Tripartite Motif (TRIM) family has progressively attracted increasing interest
during the last two decades. The presence of a distinctive amino-terminal module …

In addition to CD4+ T lymphocytes, myeloid cells and, particularly, differentiated
macrophages are targets of human immunodeficiency virus type-1 (HIV-1) infection via the …