Aging is one of the most promising risk factors for vascular diseases, however, the precise
mechanisms mediating aging-related pathologies are not fully understood. Amyloid beta …

Alzheimer disease (AD) models are based on the notion that abnormal protein aggregation
is the primary event in AD, which begins a decade or longer prior to symptom onset, and …

Approximately 40% of dementia cases could be prevented or delayed by modifiable risk
factors related to lifestyle and environment. These risk factors, such as depression and …

Objectives Adults without diabetes are not completely healthy; they are probably
heterogeneous with several potential health problems. The management of hemoglobin A1c …

Background and Objectives Hippocampal volume (HV) atrophy is a well-known biomarker of
memory impairment. However, compared with β-amyloid (Aβ) and tau imaging, it is less …

Epidemiological studies show that modifiable risk factors account for about 40% of the
population variability in risk of developing dementia, including sporadic Alzheimer's disease …

Vascular dysfunction is increasingly recognized as an important contributor to the
pathogenesis of Alzheimer's disease. Alterations in vascular endothelial growth factor …

In addition to amyloid and tau pathology, elevated systemic vascular risk, white matter injury,
and reduced cerebral blood flow contribute to late-life cognitive decline. Given the strong …

Understanding whether vascular risk factors (VRFs) synergistically potentiate Alzheimer's
disease (AD) progression is important in the context of emerging treatments for preclinical …

Background Electroacupuncture (EA) could represent a clinically effective treatment strategy
for patients with vascular cognitive impairment no dementia (VCIND). This randomized trial …