The neuroepithelial stem cell protein, or Nestin, is a cytoskeletal intermediate filament
initially characterized in neural stem cells. However, current extensive evidence obtained in …

Glioblastoma (GBM) remains the most lethal and common primary brain tumor, even after
treatment with multiple therapies, such as surgical resection, chemotherapy, and radiation …

The crucial role of cancer stem cells (CSC s) in the pathology of malignant diseases has
been extensively studied during the last decade. Nestin, a class VI intermediate filament …

BACKGROUND: Adult neurogenesis is coupled to angiogenesis in neurogenic niches in the
dentate gyrus (DG) and increased by antidepressants in rodents. We hypothesized that, in …

The p53 tumor suppressor coordinates a series of antiproliferative responses that restrict the
expansion of malignant cells, and as a consequence, p53 is lost or mutated in the majority of …

Protein N-myristoylation is a ubiquitous co-and post-translational modification that has been
implicated in the development and progression of a range of human diseases. Here, we …

One of the prevailing hypotheses suggests schizophrenia as a neurodevelopmental
disorder, involving dysfunction of dopaminergic and glutamatergic systems. Accumulating …

Cytoskeletal proteins, which consist of different sub-families of proteins including
microtubules, actin and intermediate filaments, are essential for survival and cellular …

Background Recent epidemiologic studies suggesting that there were differences in cancer
recurrence contingent on anesthetic regimens have raised the possibility that μ-opioid …

Neurons and glial cells in the developing brain arise from neural progenitor cells (NPCs).
Nestin, an intermediate filament protein, is thought to be expressed exclusively by NPCs in …