Flibanserin has preferential affinity for serotonin 5‐HT1A, dopamine D4, and serotonin 5‐
HT2A receptors. In vitro and in microiontophoresis, flibanserin behaves as a 5‐HT1A …

Since the development of chemical neuroanatomical tools in the 1960s, a tremendous
wealth of information has been generated on the anatomical components of the serotonergic …

We have examined the distribution of 5-HT1A and 5-HT2A receptor mRNAs in post-mortem
human hippocampus, neocortex, raphe nuclei, cerebellum and basal ganglia using in situ …

Abstract SEP-363856 (SEP-856) is a novel antipsychotic under clinical development. It
displays a unique pattern of receptor interaction, with only weak (partial agonist) activity at …

Objective: To investigate the efficacy and safety of clozapine in the treatment of levodopa-
induced dyskinesias (LID) in patients with severe Parkinson disease (PD). Methods: Fifty …

Serotonin-5-HT1A receptors were measured with [3H] 8-hydroxy-2-(di-n-propyl)
aminotetralin ([3H] 8-OH-DPAT) in postmortem prefrontal cortex of 12 pairs of subjects with …

Convergent evidence suggests that serotonin 5-HT1A receptor (5-HT1AR) agonists reduce l-
DOPA-induced dyskinesia by auto-regulating aberrant release of l-DOPA-derived dopamine …

Abstract Serotonin 1A (5‐HT1A) receptors are found in high densities in prefrontal cortex.
However, their distribution within cortical cell populations is unknown in both humans and …

Depression, an emotion regulation disorder, is a prevalent mental illness in the world.
Meanwhile, traditional Chinese medicine (TCM) has been increasingly regarded as a …

Abstract Serotonin (5-hydroxytryptamine; 5HT) a monoamine neurotransmitter mediates a
wide range of physiological actions in the human body. For example 5HT is implicated in …