Despite mixed findings, increasing evidence suggests that people with first-episode
psychosis (FEP) show increased pro-inflammatory and pro-oxidative status. We used the …

Both the discovery of biomarkers of schizophrenia and the verification of biological
hypotheses of schizophrenia are an essential part of the process of understanding the …

Tobacco and alcohol use are heritable behaviours associated with 15% and 5.3% of
worldwide deaths, respectively, due largely to broad increased risk for disease and injury …

Accumulating evidence suggests that gut microbiota plays a role in the pathogenesis of
schizophrenia via the microbiota–gut–brain axis. This study sought to investigate whether …

Recent studies suggested that microglia, the primary brain immune cells, can affect circuit
connectivity and neuronal function,. Microglia infiltrate the neuroepithelium early in …

Epigenetic modifications are increasingly recognized to play a role in the etiology and
pathophysiology of schizophrenia and other psychiatric disorders with developmental …

Positron emission tomography (PET) imaging with radiotracers that target translocator
protein 18 kDa (TSPO) has become a popular approach to assess putative …

Importance The use of high-field magnetic resonance spectroscopy (MRS) in multiple brain
regions of a large population of human participants facilitates in vivo study of localized or …

Biomarker-guided treatments are needed in psychiatry, and previous data suggest oxidative
stress may be a target in schizophrenia. A previous add-on trial with the antioxidant N …

Glutamate is the most abundant excitatory neurotransmitter, present at the bulk of cortical
synapses, and participating in many physiologic and pathologic processes ranging from …