The double-edged sword: Harnessing PD-1 blockade in tumor and autoimmunity
Immune checkpoint blockade has demonstrated success in treating cancer but can lead to
immune-related adverse events (irAEs), illustrating the centrality of these pathways in …
immune-related adverse events (irAEs), illustrating the centrality of these pathways in …
[HTML][HTML] Immune checkpoints on T and NK cells in the context of HBV infection: Landscape, pathophysiology and therapeutic exploitation
In hepatitis B virus (HBV) infection, the interplay between the virus and the host immune
system is crucial in determining the pathogenesis of the disease. Patients who fail to mount …
system is crucial in determining the pathogenesis of the disease. Patients who fail to mount …
Exhausted phenotype of circulating CD8+ T cell subsets in hepatitis B virus carriers
D Jiang, C Chen, D Yan, X Zhang, X Liu, D Yan, D Cui… - BMC immunology, 2022 - Springer
Background Chronic hepatitis B virus (HBV) infection is characterized by the presence of
dysfunctional exhausted CD8+ T cells that hamper viral control. We investigated the …
dysfunctional exhausted CD8+ T cells that hamper viral control. We investigated the …
[HTML][HTML] Immune response and treatment targets of chronic hepatitis B virus infection: innate and adaptive immunity
P Zheng, Y Dou, Q Wang - Frontiers in Cellular and Infection …, 2023 - frontiersin.org
Chronic hepatitis B viral (HBV) infection is a major global public health risk that threatens
human life and health, although reaching and vaccinating people have increased. The …
human life and health, although reaching and vaccinating people have increased. The …
PD-L1 upregulation by IFN-α/γ-mediated Stat1 suppresses anti-HBV T cell response
LL Liu, J Hou, Y Xu, L Qin, W Liu, H Zhang, Y Li… - PLoS …, 2020 - journals.plos.org
Programmed death ligand 1 (PD-L1) has been recently shown to be a major obstacle to
antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ …
antiviral immunity by binding to its receptor programmed death 1 (PD-1) on specific IFN-γ …
Soluble type immune checkpoint regulators using multiplex luminex immunoassay in chronic hepatitis B patients
A Fadriquela, CS Kim, KJ Lee, SH Kang… - Journal of Clinical …, 2021 - jcp.bmj.com
Aims Soluble immune checkpoint regulators (sICs) were reported to have clinical impact on
the diagnosis and progress of various diseases. This study compared the serum levels of 16 …
the diagnosis and progress of various diseases. This study compared the serum levels of 16 …
Immunological and senescence biomarker profiles in patients after spontaneous clearance of hepatitis C virus: gender implications for long-term health risk
R Martín-Escolano, EJ Vidal-Alcántara, J Crespo… - Immunity & …, 2023 - Springer
Background About 25% of patients with acute hepatitis C virus (HCV) infection show
spontaneous clearance within the first six months of infection but may remain at risk of …
spontaneous clearance within the first six months of infection but may remain at risk of …
[HTML][HTML] Heterogeneity of immune control in chronic hepatitis B virus infection: Clinical implications on immunity with interferon-α treatment and retreatment
GQ Yin, KP Chen, XC Gu - World Journal of Gastroenterology, 2022 - ncbi.nlm.nih.gov
Hepatitis B virus (HBV) infection is a global public health issue. Interferon-α (IFN-α)
treatment has been used to treat hepatitis B for over 20 years, but fewer than 5% of Asians …
treatment has been used to treat hepatitis B for over 20 years, but fewer than 5% of Asians …
[HTML][HTML] Recent advances in understanding T cell activation and exhaustion during HBV infection
L Wang, X Zeng, Z Wang, L Fang, J Liu - Virologica Sinica, 2023 - Elsevier
Chronic hepatitis B virus (HBV) infection remains a major public health concern globally,
and T cell responses are widely believed to play a pivotal role in mediating HBV clearance …
and T cell responses are widely believed to play a pivotal role in mediating HBV clearance …
Exhaustion of CD8+ T Cells in HBV Infection: Searching for Serological Markers
L Peng, J Feng, X Liu - Annals of Clinical & Laboratory Science, 2023 - Assoc Clin Scientists
Objective Chronic infection of the hepatitis B virus (HBV) is associated with the dysfunction
and exhaustion of CD8+ T cells, which are crucial in controlling HBV. While clinical …
and exhaustion of CD8+ T cells, which are crucial in controlling HBV. While clinical …