The physiology, pathology, and pharmacology of voltage-gated calcium channels and their future therapeutic potential

GW Zamponi, J Striessnig, A Koschak… - Pharmacological …, 2015 - ASPET
Voltage-gated calcium channels are required for many key functions in the body. In this
review, the different subtypes of voltage-gated calcium channels are described and their …

The genetics of bipolar disorder

FJA Gordovez, FJ McMahon - Molecular psychiatry, 2020 - nature.com
Bipolar disorder (BD) is one of the most heritable mental illnesses, but the elucidation of its
genetic basis has proven to be a very challenging endeavor. Genome-Wide Association …

[PDF][PDF] Neuronal voltage-gated calcium channels: structure, function, and dysfunction

BA Simms, GW Zamponi - Neuron, 2014 - cell.com
Voltage-gated calcium channels are the primary mediators of depolarization-induced
calcium entry into neurons. There is great diversity of calcium channel subtypes due to …

Targeting voltage-gated calcium channels in neurological and psychiatric diseases

GW Zamponi - Nature reviews Drug discovery, 2016 - nature.com
Voltage-gated calcium channels are important regulators of brain, heart and muscle
functions, and their dysfunction can give rise to pathophysiological conditions ranging from …

Neuroimmunology and neuroepigenetics in the establishment of sex differences in the brain

MM McCarthy, BM Nugent, KM Lenz - Nature Reviews Neuroscience, 2017 - nature.com
The study of sex differences in the brain is a topic of neuroscientific study that has broad
reaching implications for culture, society and biomedical science. Recent research in rodent …

The tail suspension test

A Can, DT Dao, CE Terrillion, SC Piantadosi… - JoVE (Journal of …, 2012 - jove.com
The tail-suspension test is a mouse behavioral test useful in the screening of potential
antidepressant drugs, and assessing of other manipulations that are expected to affect …

Sex differences in the brain: the not so inconvenient truth

MM McCarthy, AP Arnold, GF Ball… - Journal of …, 2012 - Soc Neuroscience
In 2001 the Institute of Medicine, a branch of the National Academy of Sciences in the USA,
concluded that many aspects of both normal and pathological brain functioning exhibit …

Sex differences in animal models of psychiatric disorders

N Kokras, C Dalla - British journal of pharmacology, 2014 - Wiley Online Library
Psychiatric disorders are characterized by sex differences in their prevalence,
symptomatology and treatment response. Animal models have been widely employed for …

[PDF][PDF] Genetic background limits generalizability of genotype-phenotype relationships

LJ Sittig, P Carbonetto, KA Engel, KS Krauss… - Neuron, 2016 - cell.com
Genome-wide association studies (GWASs) have identified numerous loci that influence risk
for psychiatric diseases. Genetically engineered mice are often used to characterize genes …

[HTML][HTML] Genetic disruption of voltage-gated calcium channels in psychiatric and neurological disorders

S Heyes, WS Pratt, E Rees, S Dahimene, L Ferron… - Progress in …, 2015 - Elsevier
This review summarises genetic studies in which calcium channel genes have been
connected to the spectrum of neuropsychiatric syndromes, from bipolar disorder and …