Tryptophan (Trp) metabolism primarily involves the kynurenine, 5-hydroxytryptamine, and
indole pathways. A variety of bioactive compounds produced via Trp metabolism can …

Gut-liver-brain axis is a three-way highway of information interaction system among the
gastrointestinal tract, liver, and nervous systems. In the past few decades, breakthrough …

Tumour cells have exquisite flexibility in reprogramming their metabolism in order to support
tumour initiation, progression, metastasis and resistance to therapies. These reprogrammed …

Background The gut microbiome plays a pivotal role in the progression of sepsis. However,
the specific mechanism of gut microbiota and its metabolites involved in the process of …

The gut is colonized by many commensal microorganisms, and the diversity and metabolic
patterns of microorganisms profoundly influence the intestinal health. These microbial …

Extensive studies demonstrate the importance of the STING1 (also known as STING) protein
as a signaling hub that coordinates immune and autophagic responses to ectopic DNA in …

The aryl hydrocarbon receptor (AhR) belongs to the essential helix-loop-helix transcription
factors family. This receptor has a central role in determining host physiology and a variety of …

In recent years, the incidence rate of diabetes mellitus (DM), including type 1 diabetes
mellitus (T1DM), type 2 diabetes mellitus (T2DM), and gestational diabetes mellitus (GDM) …

Inflammatory bowel disease represents one of the most life-altering gastrointestinal
pathologies, with its multifactorial nature and unclear physiopathology. The most relevant …

Pharmacological treatment of inflammatory bowel disease (IBD) is inefficient and difficult to
discontinue appropriately, and enterobacterial interactions are expected to provide a new …