Studying the evolution of catalytically promiscuous enzymes like those from the N-
succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily can …

Understanding how enzyme specificity evolves will provide guiding principles for protein
engineering and function prediction. The o-succinylbenzoate synthase (OSBS) family is an …

The study first reported the efficient lipase catalysis of aza-Markovnikov addition of N-
heterocycles to vinyl esters in organic media. After screening the enzyme sources and …

Mycobacterium tuberculosis, the cause of tuberculosis, is one of the most devastating
human pathogens. New drugs for its control are urgently needed. Menaquinone, also known …

Vitamin K2, or menaquinone, is an essential cofactor for many organisms and the enzymes
involved in its biosynthesis are potential antimicrobial drug targets. One of these enzymes, 1 …

N-Acylamino acid racemase (NAAAR) catalyzes the racemization of N-acylamino acids and
can be used in concert with an aminoacylase to produce enantiopure α-amino acids, a …

Thermobifida fusca o-succinylbenzoate synthase (OSBS), a member of the enolase
superfamily that catalyzes a step in menaquinone biosynthesis, has an amino acid …

The bactericidal activity of several antibiotics partially relies on the production of reactive
oxygen species (ROS), which is generally linked to enhanced respiration and requires the …

The N-succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily
from the enolase superfamily contains different enzymes showing promiscuous N …

The chemical selectivity between Markovnikov addition and acylation in the reaction of thiols
and vinyl esters were developed. The addition reaction was efficiently catalyzed by CAL-B at …