Comparison of Alicyclobacillus acidocaldarius o-Succinylbenzoate Synthase to Its Promiscuous N-Succinylamino Acid Racemase/o-Succinylbenzoate Synthase …
D Odokonyero, AW McMillan, UA Ramagopal… - Biochemistry, 2018 - ACS Publications
Studying the evolution of catalytically promiscuous enzymes like those from the N-
succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily can …
succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily can …
Residues Required for Activity in Escherichia coli o-Succinylbenzoate Synthase (OSBS) Are Not Conserved in All OSBS Enzymes
WW Zhu, C Wang, J Jipp, L Ferguson, SN Lucas… - Biochemistry, 2012 - ACS Publications
Understanding how enzyme specificity evolves will provide guiding principles for protein
engineering and function prediction. The o-succinylbenzoate synthase (OSBS) family is an …
engineering and function prediction. The o-succinylbenzoate synthase (OSBS) family is an …
Two lipase-catalyzed sequential synthesis of drug derivatives in organic media
B Liu, X Qian, Q Wu, X Lin - Enzyme and microbial technology, 2008 - Elsevier
The study first reported the efficient lipase catalysis of aza-Markovnikov addition of N-
heterocycles to vinyl esters in organic media. After screening the enzyme sources and …
heterocycles to vinyl esters in organic media. After screening the enzyme sources and …
Structure of naphthoate synthase (MenB) from Mycobacterium tuberculosis in both native and product-bound forms
Mycobacterium tuberculosis, the cause of tuberculosis, is one of the most devastating
human pathogens. New drugs for its control are urgently needed. Menaquinone, also known …
human pathogens. New drugs for its control are urgently needed. Menaquinone, also known …
Structure of Staphylococcus aureus 1, 4-dihydroxy-2-naphthoyl-CoA synthase (MenB) in complex with acetoacetyl-CoA
V Ulaganathan, MF Agacan, L Buetow… - … Section F: Structural …, 2007 - journals.iucr.org
Vitamin K2, or menaquinone, is an essential cofactor for many organisms and the enzymes
involved in its biosynthesis are potential antimicrobial drug targets. One of these enzymes, 1 …
involved in its biosynthesis are potential antimicrobial drug targets. One of these enzymes, 1 …
Structural basis for catalytic racemization and substrate specificity of an N-acylamino acid racemase homologue from Deinococcus radiodurans
WC Wang, WC Chiu, SK Hsu, CL Wu, CY Chen… - Journal of molecular …, 2004 - Elsevier
N-Acylamino acid racemase (NAAAR) catalyzes the racemization of N-acylamino acids and
can be used in concert with an aminoacylase to produce enantiopure α-amino acids, a …
can be used in concert with an aminoacylase to produce enantiopure α-amino acids, a …
Divergent Evolution of Ligand Binding in the o-Succinylbenzoate Synthase Family
D Odokonyero, S Ragumani, MS Lopez… - Biochemistry, 2013 - ACS Publications
Thermobifida fusca o-succinylbenzoate synthase (OSBS), a member of the enolase
superfamily that catalyzes a step in menaquinone biosynthesis, has an amino acid …
superfamily that catalyzes a step in menaquinone biosynthesis, has an amino acid …
Membrane depolarization kills dormant Bacillus subtilis cells by generating a lethal dose of ROS
DA Gray, B Wang, M Sidarta, FA Cornejo… - Nature …, 2024 - nature.com
The bactericidal activity of several antibiotics partially relies on the production of reactive
oxygen species (ROS), which is generally linked to enhanced respiration and requires the …
oxygen species (ROS), which is generally linked to enhanced respiration and requires the …
N-succinylamino acid racemases: Enzymatic properties and biotechnological applications
S Martínez-Rodríguez, P Soriano-Maldonado… - … et Biophysica Acta (BBA …, 2020 - Elsevier
The N-succinylamino acid racemase/o-succinylbenzoate synthase (NSAR/OSBS) subfamily
from the enolase superfamily contains different enzymes showing promiscuous N …
from the enolase superfamily contains different enzymes showing promiscuous N …
Controllable enzymatic Markovnikov addition and acylation of thiols to vinyl esters
FW Lou, BK Liu, JL Wang, Q Pan, XF Lin - Journal of Molecular Catalysis B …, 2009 - Elsevier
The chemical selectivity between Markovnikov addition and acylation in the reaction of thiols
and vinyl esters were developed. The addition reaction was efficiently catalyzed by CAL-B at …
and vinyl esters were developed. The addition reaction was efficiently catalyzed by CAL-B at …