The α 7-type nicotinic acetylcholine receptor is one of the most unique and interesting of all
the members of the cys-loop superfamily of ligand-gated ion channels. Since it was first …

The past decade has witnessed an enormous increase in our knowledge of the variety and
complexity of neuropathological and neurochemical changes in Alzheimer's disease …

Neurotoxins generally inhibit or promote the release of neurotransmitters or bind to
receptors that are located in the pre-or post-synaptic membranes, thereby affecting …

Acute and chronic nicotine administration has been repeatedly been found in our laboratory
to improve working memory performance of normal adult rats in the radial-arm maze. The …

Cholinergic dysfunction is one of the cornerstones of Alzheimer's disease (AD) pathology.
Reviewed here is evidence evaluating relationships between smoking, nicotine exposure …

Age-related changes in nicotinic acetylcholine receptor (nAChR) subunit α4 and β2
messenger RNA (mRNA) expression in the postmortem human frontal cortex and …

Nicotine alters cognitive functions in animals and humans most likely by modification of
brain plasticity. In the human brain, it alters plasticity induced by transcranial direct current …

Epidemiological studies regarding Alzheimer's disease (AD) in smokers currently suggest
inconsistent results. The clinicopathological findings also vary as to how AD pathology is …

Publisher Summary Four major and distinct therapeutic interventions for the treatment of
Alzheimer disease (AD) have been envisioned in order to:(1) achieve a symptomatic …

The onset and severity of age-related loss of neuronal nicotinic acetylcholine receptor
(nAChR) expression in the mammalian hippocampus can vary considerably between …