[HTML][HTML] Intersection of pathological tau and microglia at the synapse
T Vogels, AN Murgoci, T Hromádka - Acta neuropathologica …, 2019 - Springer
Tauopathies are a heterogenous class of diseases characterized by cellular accumulation of
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …
aggregated tau and include diseases such as Alzheimer's disease (AD), progressive …
[HTML][HTML] Peptide-based vaccines for neurodegenerative diseases: Recent endeavors and future perspectives
V Vassilakopoulou, CE Karachaliou, A Evangelou… - Vaccines, 2021 - mdpi.com
The development of peptide-based vaccines for treating human neurodegenerative
diseases has been the eventual aim of many research endeavors, although no active …
diseases has been the eventual aim of many research endeavors, although no active …
[HTML][HTML] Physiological expression of mutated TAU impaired astrocyte activity and exacerbates β-amyloid pathology in 5xFAD mice
D Farfara, M Sooliman, L Avrahami, TG Royal… - Journal of …, 2023 - Springer
Background Alzheimer's disease (AD) is the leading cause of dementia in the world. The
pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies …
pathology of AD is affiliated with the elevation of both tau (τ) and β-amyloid (Aβ) pathologies …
Current peptide vaccine and immunotherapy approaches against Alzheimer's disease
CMT Parrocha, JS Nowick - Peptide Science, 2023 - Wiley Online Library
Peptide vaccines and immunotherapies against aggregating proteins involved in the
pathogenesis and progression of Alzheimer's disease (AD)—the β‐amyloid peptide (Aβ) …
pathogenesis and progression of Alzheimer's disease (AD)—the β‐amyloid peptide (Aβ) …
[HTML][HTML] Brain targeting of 9c, 11t-Conjugated Linoleic Acid, a natural calpain inhibitor, preserves memory and reduces Aβ and P25 accumulation in 5XFAD mice
O Binyamin, K Nitzan, K Frid, Y Ungar, H Rosenmann… - Scientific reports, 2019 - nature.com
Deregulation of Cyclin-dependent kinase 5 (CDK5) by binding to the activated calpain
product p25, is associated with the onset of neurodegenerative diseases, such as …
product p25, is associated with the onset of neurodegenerative diseases, such as …
[HTML][HTML] Active immunization with tau epitope in a mouse model of tauopathy induced strong antibody response together with improvement in short memory and …
A Joly-Amado, H Davtyan, K Serraneau, P Jules… - Neurobiology of …, 2020 - Elsevier
Abnormal tau hyperphosphorylation and its aggregation into neurofibrillary tangles are a
hallmark of tauopathies, neurodegenerative disorders that include Alzheimer's disease (AD) …
hallmark of tauopathies, neurodegenerative disorders that include Alzheimer's disease (AD) …
[HTML][HTML] Both amyloid-β peptide and tau protein are affected by an anti-amyloid-β antibody fragment in elderly 3xTg-AD mice
AR Roda, L Montoliu-Gaya, G Serra-Mir… - International journal of …, 2020 - mdpi.com
Alzheimer's disease (AD) is the most common dementia worldwide. According to the
amyloid hypothesis, the early accumulation of the Aβ-peptide triggers tau phosphorylation …
amyloid hypothesis, the early accumulation of the Aβ-peptide triggers tau phosphorylation …
[HTML][HTML] Peptide interference with APP and tau association: relevance to Alzheimer's disease amelioration
The two major proteins involved in Alzheimer's disease (AD) are the amyloid precursor
protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other …
protein (APP) and Tau. Here, we demonstrate that these two proteins can bind to each other …
[HTML][HTML] The Beneficial Effect of Mitochondrial Transfer Therapy in 5XFAD Mice via Liver–Serum–Brain Response
S Sweetat, K Nitzan, N Suissa, Y Haimovich… - Cells, 2023 - mdpi.com
We recently reported the benefit of the IV transferring of active exogenous mitochondria in a
short-term pharmacological AD (Alzheimer's disease) model. We have now explored the …
short-term pharmacological AD (Alzheimer's disease) model. We have now explored the …
Complicaciones centrales en un modelo murino de enfermedad de alzheimer y diabetes mellitus: papel de la liraglutida
MJ Carranza-Naval - 2022 - rodin.uca.es
La enfermedad de Alzheimer (EA) es la causa más común de demencia. Se caracteriza
neuropatológicamente por el depósito del péptido β-amiloide (βA), la presencia de ovillos …
neuropatológicamente por el depósito del péptido β-amiloide (βA), la presencia de ovillos …