Cancers represent complex ecosystems comprising tumor cells and a multitude of non-
cancerous cells, embedded in an altered extracellular matrix. The tumor microenvironment …

Tumor cells do not exist in isolation in vivo, and carcinogenesis depends on the surrounding
tumor microenvironment (TME), composed of a myriad of cell types and biophysical and …

By providing spatial, molecular and morphological data over time, live-cell imaging can
provide a deeper understanding of the cellular and signalling events that determine cancer …

The advent of immunotherapy, a groundbreaking advancement in cancer treatment, has
given rise to the prominence of the tumor microenvironment (TME) as a critical area of …

Despite many advances, metastatic disease remains essentially uncurable. Thus, there is an
urgent need to better understand mechanisms that promote metastasis, drive tumor …

Cancer development, progression and therapy response are heterogeneous and patient-
specific. The biological and physical properties of tumour cells and their surrounding tissue …

The genetic alterations contributing to migration proficiency, a phenotypic hallmark of
metastatic cells required for colonizing distant organs, remain poorly defined. Here, we used …

Label-free imaging through two-photon autofluorescence (2PAF) of NAD (P) H allows for
non-destructive and high-resolution visualization of cellular activities in living systems …

Detection of circulating tumor cells (CTCs) is important for early cancer diagnosis, prediction
of postoperative recurrence, and individualized treatment. However, it is still challenging to …

Cancer immunotherapy has developed rapidly in recent years and stands as one of the most
promising techniques for combating cancer. To develop and optimize cancer …