Ubiquitin specific protease (USP) 2 is a multifunctional deubiquitinating enzyme. USP2
modulates cell cycle progression, and therefore carcinogenesis, via the deubiquitination of …

F-box proteins are involved in multiple cellular processes through ubiquitylation and
consequent degradation of targeted substrates. Any significant mutation in F-box protein …

Simple Summary The roles of “like-Smith”(LSM) proteins in breast cancer development and
their clinical relevance remain unclear. In this study, multiple analyses based on 3593 …

Purpose Triple-negative breast cancer (TNBC) is an aggressive disease lacking specific
biomarkers to guide treatment decisions. We evaluated the combined prognostic impact of …

Human RecQ helicases play diverse roles in the maintenance of genomic stability.
Inactivating mutations in 3 of the 5 human RecQ helicases are responsible for the …

The ubiquitin proteasome system (UPS) is critically important for cellular homeostasis and
affects virtually all key functions in normal and neoplastic cells. Currently, a comprehensive …

The of cellular composition pr proteins protein can be cumulati ocesses vely inv r ol ef v is ed
vital in the for maint the maint enance enance of cellular of cell aggr of pr eg ot at eostasis …

Glioma is the most common type of primary malignant tumor in the central nervous system.
Tumor recurrence and progression are common in lower-grade glioma (LGG). Immune …

Simple Summary Multiple drug resistant cancers develop all too soon in patients who
received successful cancer treatment. A lack of treatment options often leaves palliative care …

Impaired protein homeostasis, though well established in age-related disorders, has been
recently linked with the pathogenesis of myeloproliferative neoplasms (MPNs). However …