Depression is a heterogeneous mental disorder characterized by feelings of sadness and
loss of interest that render the subject unable to handle basic daily activities such as …

Exogenous administration of inflammatory stimuli to humans and laboratory animals and
chronic endogenous inflammatory states lead to motivational deficits and ultimately …

Importance Insufficient treatment response and resulting chronicity constitute a major
problem in depressive disorders. Remission rates range as low as 15% to 40% and …

There is increasing evidence showing that inflammation is associated with depression in
humans. Hesperidin, a natural bioflavonoid, has performed excellent effects on depression …

Background: N6 adenosine methylation (m6A) is the most abundant internal RNA
modification in eukaryotic cells. Dysregulation of m6A has been associated with the …

Background Suicidal behaviors have become a serious public health concern globally due
to the economic and human cost of suicidal behavior to individuals, families, communities …

Background Some evidence support the notion that microglia activation in acute state of
schizophrenia might contribute to damage of oligodendrocytes and myelinated fibers …

Stroke is a group of diseases resulting from cerebral vascular rupture or obstruction and
subsequent brain blood circulation disorder, leading to rapid neurological deficits. Ischemic …

The field of vascular contributions to cognitive impairment and dementia (VCID) is evolving
rapidly. Research in VCID encompasses topics aiming to understand, prevent, and treat the …

Background Microglia are resident innate immune cells in the brain, and activation of these
myeloid cells results in secretion of a variety of pro-inflammatory molecules, leading to the …