Fibrosis is the endpoint of pathological remodeling. This process contributes to the
pathogenesis of several chronic disorders and aging-associated organ damage. Different …

The collagen family contains 28 proteins, predominantly expressed in the extracellular
matrix (ECM) and characterized by a triple-helix structure. Collagens undergo several …

The extracellular matrix (ECM) creates a multifaceted system for the interaction of diverse
structural proteins, matricellular molecules, proteoglycans, hyaluronan, and various …

Liver disease has become a major health problem worldwide due to its high morbidity and
mortality. In recent years, a large body of literature has shown that mesenchymal stem cell …

Long non-coding RNAs (lncRNAs) are the key components of non-coding RNAs (ncRNAs)
with a length of 200 nucleotides. They are transcribed from the so-called “dark matter” of the …

Background Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis.
We previously demonstrated that exosomes derived from natural killer (NK) cells (NK-Exo) …

Liver fibrosis, a chronic inflammatory healing reaction, progresses to hepatocirrhosis without
effective intervention. Hesperetin derivative (HD-16), a monomer compound derived from …

Activation of hepatic stellate cells (HSCs) is a prominent driver of liver fibrosis. This study
was designed to investigate the effect of exosomes derived from natural killer (NK) cells on …

The prevalence of non-alcoholic fatty liver disease (NAFLD) and atherosclerosis remain
high, which is primarily due to widespread adoption of a western diet and sedentary lifestyle …

Excessive transforming growth factor β1 (TGF-β1) secreted by activated hepatic stellate cells
(aHSCs) aggravates liver fibrosis via over-activation of TGF-β1-mediated signaling …