Interactions between the immune and nervous systems are of central importance in
neuropathic pain, a common and debilitating form of chronic pain caused by a lesion or …

Current analgesics predominately modulate pain transduction and transmission in neurons
and have limited success in controlling disease progression. Accumulating evidence …

Paralleling the activation of dorsal horn microglia after peripheral nerve injury is a significant
expansion and proliferation of macrophages around injured sensory neurons in dorsal root …

The CNS is endowed with an elaborated response repertoire termed'neuroinflammation',
which enables it to cope with pathogens, toxins, traumata and degeneration. On the basis of …

The peripheral (PNS) and central nervous system (CNS) are delicate structures, highly
sensitive to homeostatic changes—and crucial for basic vital functions. Thus, a selection of …

Inflammation is the process by which an organism responds to tissue injury involving both
immune cell recruitment and mediator release. Diverse causes of neuropathic pain are …

Chronic low back pain (CLBP), lasting> 3 months, is the end result of multiple pathogenic
factors. Unfortunately, little is known about CLBP pathogenesis, which limits its …

Neuropathic pain represents a major problem in clinical medicine because it causes
debilitating suffering and is largely resistant to currently available analgesics. A …

It is increasingly clear that systemic inflammation has both adaptive and deleterious effects
on the brain. However, detailed comparisons of brain effects of systemic challenges with …

Peripheral nerve injuries induce a pronounced immune reaction within the spinal cord,
largely governed by microglia activation in both the dorsal and ventral horns. The …