Within the past decade, the field of immunotherapy has revolutionized the treatment of many
cancers with the development and regulatory approval of various immune-checkpoint …

In cancer-immunity cycle, the immune checkpoint PD1 and its ligand PDL1 act as
accomplices to help tumors resist to immunity-induced apoptosis and promote tumor …

TCF1 and its homologue LEF1 are historically known as effector transcription factors
downstream of the WNT signalling pathway and are essential for early T cell development …

Immune checkpoint inhibitors (ICI) targeting CTLA-4 and the PD-1/PD-L1 axis have shown
unprecedented clinical activity in several types of cancer and are rapidly transforming the …

CD8 T cells comprising the memory pool display considerable heterogeneity, with individual
cells differing in phenotype and function. This review will focus on our current understanding …

Studies have reported a positive correlation between elevated CD8+ T cells in the tumor
microenvironment (TME) and good prognosis in cancer. However, the mechanisms linking T …

Influenza A viruses (IAVs) are contagious pathogens responsible for severe respiratory
infection in humans and animals worldwide. Upon detection of IAV infection, host immune …

Exhausted CD8 T (Tex) cells are a distinct cell lineage that arise during chronic infections
and cancers in animal models and humans. Tex cells are characterized by progressive loss …

During immune challenge, T lymphocytes engage pathways of anabolic metabolism to
support clonal expansion and the development of effector functions. Here we report a critical …

For the first time in decades, patients with difficult-to-treat cancers such as advanced stage
metastatic melanoma are being offered a glimpse of hope in the form of immunotherapies …