Kynurenine (KYN), a main metabolite of tryptophan in mammals, is a direct precursor of
kynurenic acid, anthranilic acid and 3-hydroxykynurenine (3-HK). Under physiological …

Physical exercise may improve cognitive function by modulating molecular and cellular
mechanisms within the brain. We propose that the facilitation of long-term synaptic …

The mechanisms by which exercise benefits human health remain incompletely understood.
With the emergence of omics techniques, mapping of the molecular response to exercise is …

Alzheimer's disease (AD) is the most common cause of dementia and there is currently no
cure. Novel approaches to treat AD and curb the rapidly increasing worldwide prevalence …

Physical exercise can produce changes in the microbiota, conferring health benefits through
mechanisms that are not fully understood. We sought to determine the changes driven by …

This systematic review aimed to synthesise the results from studies investigating the effects
of prebiotics and probiotics on kynurenine pathway metabolism. Thirteen studies were …

Objectives Exercise‐induced cellular mobilization might play a role in treatment and
prevention of several diseases. However, little is known about the impact of different …

Objective To examine acute (single-bout) and training effects of high-intensity interval
training (HIIT) vs standard exercise therapy (moderate continuous training [MCT]) on plasma …

Major depressive disorder (MDD) has a high prevalence and is a major contributor to the
global burden of disease. This psychiatric disorder results from a complex interaction …

Many of the exercise-related health-promoting effects are attributed to beneficial
immunomodulation. The restoration of immune homeostasis is context-dependent, meaning …