The determination of the crystal structures of small-molecule transporters has shed light on
the conformational changes that take place during structural isomerization from outward-to …

Ligand-induced activation of G protein–coupled receptors (GPCRs) is a key mechanism
permitting communication between cells and organs. Enormous progress has recently …

The proteins that form the permeation pathway of mechanosensory transduction channels in
inner-ear hair cells have not been definitively identified. Genetic, anatomical, and …

Chemogenetic characterization through in vitro evolution combined with whole-genome
analysis can identify antimalarial drug targets and drug-resistance genes. We performed a …

The crystal structure of the dimeric membrane domain of human Band 3 1, the red cell
chloride/bicarbonate anion exchanger 1 (AE1, SLC4A1), provides a structural context for …

Here, we provide a protocol to generate synthetic nanobodies, known as sybodies, against
any purified protein or protein complex within a 3-week period. Unlike methods that require …

Knowledge on the mechanisms of acid and base secretion in airways has progressed
recently. The aim of this review is to summarize the known mechanisms of airway surface …

The epithelial anion transporter SLC26A9 contributes to airway surface hydration and
gastric acid production. Colocalizing with CFTR, SLC26A9 has been proposed as a target …

Zinc is essential for all organisms and yet detrimental at elevated levels. Hence,
homeostasis of this metal is tightly regulated. The Zrt/Irt-like proteins (ZIPs) represent the …

The human solute carriers (SLCs) comprise over 400 different transporters, organized into
65 families (http://slc. bioparadigms. org/) based on their sequence homology and transport …