Background Temporal trends in the incidence of pediatric-onset inflammatory bowel disease
(IBD) are controversial and a wide range of estimates have been reported worldwide. We …

IBD is a chronic disorder with disease onset ranging from early childhood to beyond the
sixth decade of life. The factors that determine the age of onset currently remain …

In the West, the incidence and prevalence of inflammatory bowel diseases has increased in
the past 50 years, up to 8–14/100,000 and 120–200/100,000 persons, respectively, for …

Background & Aims We analyzed DNA methylation patterns and transcriptomes of primary
intestinal epithelial cells (IEC) of children newly diagnosed with inflammatory bowel …

Objective: Health administrative databases can be used to track chronic diseases. The aim
of this study was to validate a case ascertainment definition of paediatric-onset inflammatory …

BACKGROUND & AIMS: The IMAgINE 1 study (NCT00409682) evaluated the safety and
efficacy of adalimumab double-blind maintenance dosing regimens following open-label …

BACKGROUND & AIMS: We evaluated the efficacy and safety of infliximab for inducing and
maintaining benefit in children with moderately to severely active ulcerative colitis (UC) …

Idiopathic inflammatory bowel diseases (IBD), Crohn's disease (CD) and ulcerative colitis
(UC), are multifactorial diseases that are manifested after disruption of a genetic …

The increase in incidences of pediatric Crohn's Disease (CD) worldwide has been strongly
linked with dietary shifts towards a Westernized diet, ultimately leading to altered gut …

The incidence and prevalence of inflammatory bowel disease (IBD) is increasing globally.
Coupled with an ageing population, the number of older patients with IBD is set to increase …