Abdominal aortic aneurysm: update on pathogenesis and medical treatments

J Golledge - Nature Reviews Cardiology, 2019 - nature.com
Abdominal aortic aneurysm (AAA) rupture is an important cause of death in adults. Currently,
the only treatment for AAA is open or endovascular surgical repair. In most parts of the …

Leveraging machine learning and artificial intelligence to improve peripheral artery disease detection, treatment, and outcomes

AM Flores, F Demsas, NJ Leeper, EG Ross - Circulation research, 2021 - Am Heart Assoc
Peripheral artery disease is an atherosclerotic disorder which, when present, portends poor
patient outcomes. Low diagnosis rates perpetuate poor management, leading to limb loss …

Lack of an effective drug therapy for abdominal aortic aneurysm

J Golledge, JV Moxon, TP Singh… - Journal of internal …, 2020 - Wiley Online Library
Abdominal aortic aneurysm (AAA) rupture is a common cause of death in adults. Current
AAA treatment is by open surgical or endovascular aneurysm repair. Rodent model and …

Aortic wall inflammation predicts abdominal aortic aneurysm expansion, rupture, and need for surgical repair

MA3RS Study Investigators - Circulation, 2017 - Am Heart Assoc
Background: Ultrasmall superparamagnetic particles of iron oxide (USPIO) detect cellular
inflammation on magnetic resonance imaging (MRI). In patients with abdominal aortic …

[HTML][HTML] Challenges and opportunities in limiting abdominal aortic aneurysm growth

J Golledge, PE Norman, MP Murphy… - Journal of vascular …, 2017 - Elsevier
Objective This review describes ongoing efforts to develop a medical therapy to limit
abdominal aortic aneurysm (AAA) growth. Methods Data from animal model studies, human …

[HTML][HTML] An intersegmental single-cell profile reveals aortic heterogeneity and identifies a novel Malat1+ vascular smooth muscle subtype involved in abdominal aortic …

L Yu, J Zhang, A Gao, M Zhang, Z Wang, F Yu… - … and Targeted Therapy, 2022 - nature.com
The developmental origin, anatomical location, and other factors contribute to aortic
heterogeneity in a physiological state. On this basis, vascular diseases occur at different …

Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm

B Liu, DJ Granville, J Golledge… - American Journal of …, 2020 - journals.physiology.org
Aortic aneurysm is a permanent focal dilation of the aorta. It is usually an asymptomatic
disease but can lead to sudden death due to aortic rupture. Aortic aneurysm-related …

Genetic and epigenetic regulation of aortic aneurysms

HW Kim, BK Stansfield - BioMed research international, 2017 - Wiley Online Library
Aneurysms are characterized by structural deterioration of the vascular wall leading to
progressive dilatation and, potentially, rupture of the aorta. While aortic aneurysms often …

[HTML][HTML] Biomechanical changes during abdominal aortic aneurysm growth

RRF Stevens, A Grytsan, J Biasetti, J Roy… - PLoS …, 2017 - journals.plos.org
The biomechanics-based Abdominal Aortic Aneurysm (AAA) rupture risk assessment has
gained considerable scientific and clinical momentum. However, such studies have mainly …

[HTML][HTML] Circulating biomarkers for the prediction of abdominal aortic aneurysm growth

P Nana, K Dakis, A Brodis, K Spanos… - Journal of Clinical …, 2021 - mdpi.com
Background: Abdominal aortic aneurysm represents a distinct group of vascular lesions, in
terms of surveillance and treatment. Screening and follow-up of patients via duplex …