Statins (3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors) are associated with
skeletal muscle complaints, including clinically important myositis and rhabdomyolysis, mild …

Context Theory and simulation suggest that randomized controlled trials (RCTs) stopped
early for benefit (truncated RCTs) systematically overestimate treatment effects for the …

ContextLowering low-density lipoprotein cholesterol (LDL-C) is known to reduce risk of
recurrent coronary heart disease in middle-aged men. However, this effect has been …

Background: Statins represent the largest selling class of cardiovascular drug in the world.
Previous randomized trials (RCTs) have demonstrated important clinical benefits with statin …

ContextPercutaneous coronary intervention (PCI) is associated with excellent short-term
improvements in ischemic symptoms, yet only three fifths of PCI patients at 5 years and one …

Anti-inflammatory and immunomodulatory effects of statins. 3-Hydroxy-3-methyl-gutaryl
coenzyme A (HMG-CoA) reductase inhibitors or statins constitute the most powerful class of …

The beneficial effects of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase
inhibitors (statins) on coronary events have generally been attributed to their …

Background We conducted a meta-analysis of patients with coronary heart disease (CHD) to
determine the effectiveness of statin therapy; whether effectiveness varied according to …

Ideal for cardiologists, surgeons, and referring physicians who need a clinical guide to
interventional procedures, Textbook of Interventional Cardiology focuses on the latest …

The role of inflammation in the development of restenosis after percutaneous coronary
interventions has been investigated in several studies. There is an interaction of …