Simple Summary Localized prostate cancer has a favorable prognosis and can be
effectively treated with radiotherapy, as well as therapies that target hormone production and …

Leukodystrophies are a class of rare heterogeneous disorders which affect the white matter
of the brain, ultimately leading to a disruption in brain development and a damaging effect …

The functional anatomy of organisms is maintained by the coordination of different systems,
which often rely on interactions between specialized cells and between macromolecules …

Down syndrome is the most common genetic cause of intellectual disability and has
previously been associated with a variety of autoimmune disorders affecting multiple organ …

Dysfunctional mutations in SAMHD1 cause Aicardi-Goutières Syndrome, an
autoinflammatory encephalopathy with elevated interferon-α levels in the cerebrospinal …

Fanconi anemia (FA) is a complex inherited bone marrow failure syndrome characterized by
chromosomal instability and defective DNA repair, causing sensitivity to DNA interstrand …

Interferons (IFNs) and IFN-related pathways play key roles in the defence against microbial
infection. However, these processes may also be activated during the pathogenesis of non …

The nuclear envelope compartmentalizes the nuclear DNA from the cytoplasm and protects,
organizes, and regulates the eukaryote genome while adapting to its environment, including …

Stimulator of interferon genes (STING), a homodimeric membrane receptor localized in the
endoplasmic reticulum, plays a pivotal role in signaling innate immune responses. Inhibitors …

Résumé Les leucodystrophies métaboliques doivent être recherchées devant toute
anomalie de la substance blanche non évocatrice d'une maladie inflammatoire ou …