ABSTRACT BTZ-043, a suicide inhibitor of the Mycobacterium tuberculosis cell wall
synthesis decaprenylphosphoryl-beta-d-ribose 2′ epimerase, is under clinical …

Mycobacterium tuberculosis possesses a dynamic cell envelope, which consists of a
peptidoglycan layer, a mycolic acid layer, and an arabinogalactan polysaccharide. This …

Nitroimidazole represents one of the most essential and unique scaffolds in drug discovery
since its discovery in the 1950s. It was K. Maeda in Japan who reported in 1953 the first …

Persister cells are transiently antibiotic-tolerant and dormant subpopulations that are
produced to escape the effects of antibiotics within biofilms or planktonic cell populations …

MALDI mass-spectrometry imaging (MALDI-MSI) is a technique capable of the label-free
identification and visualization of analytes in tissue sections. We have previously applied …

Introduction: The treatment of tuberculosis (TB) is a mature discipline, with more than 60
years of clinical experience accrued across the globe. The requisite Multi-drug treatment of …

New drugs and drugs with a novel mechanism of action are desperately needed to shorten
the duration of tuberculosis treatment, to prevent the emergence of drug resistance, and to …

Tuberculosis (TB) drug research and development efforts have resurged in the past 10 years
to meet urgent medical needs, but enormous challenges remain. These urgent needs are …

The United Nations Millennium Development Goal of reversing the global spread of
tuberculosis by 2015 has been offset by the rampant re-emergence of drug-resistant …

Mycobacterium tuberculosis (Mtb) has evolved protective and detoxification mechanisms to
maintain cytoplasmic redox balance in response to exogenous oxidative stress encountered …