Mammalian fertilization begins with the fusion of two specialized gametes, followed by major
epigenetic remodeling leading to the formation of a totipotent embryo. During the …

Drastic epigenetic reprogramming takes place during preimplantation development, leading
to the conversion of terminally differentiated gametes to a totipotent embryo. Deficiencies in …

Postnatal growth of mammalian oocytes is accompanied by a progressive gain of DNA
methylation, which is predominantly mediated by DNMT3A, a de novo DNA …

The oocyte epigenome plays critical roles in mammalian gametogenesis and
embryogenesis. Yet, how it is established remains elusive. Here, we report that histone …

INTRODUCTION Epigenetic modifications to chromatin, such as the methylation of DNA
cytosines, carry regulatory information across the generations in plants and animals …

In mammals, chromatin organization undergoes drastic reorganization during oocyte
development. However, the dynamics of three-dimensional chromatin structure in this …

Upon fertilization, terminally differentiated gametes are transformed to a totipotent zygote,
which gives rise to an embryo. How parental epigenetic memories are inherited and …

Cryopreservation has important application in assisted reproductive technology (ART). The
vitrification technique has been widely used in the cryopreservation of oocytes and embryos …

Epigenetics is the branch of genetics that studies the different mechanisms that influence
gene expression without direct modification of the DNA sequence. An ever-increasing …

Air pollution is one of the leading causes of deaths in Southeast Asian countries including
India. Exposure to air pollutants affects vital cellular mechanisms and is intimately linked …