Polymeric materials produced from fossil fuels have been intimately linked to the
development of industrial activities in the 20th century and, consequently, to the …

Advances in single-cell RNA sequencing (scRNA-seq) have allowed for comprehensive
analysis of the immune system. In this Review, we briefly describe the available scRNA-seq …

INTRODUCTION Strong genetic associations have been found for a number of psychiatric
disorders. However, understanding the underlying molecular mechanisms remains …

Rationale: It is assumed that atherosclerotic arteries contain several macrophage subsets
endowed with specific functions. The precise identity of these subsets is poorly …

Immune cells infiltrating tumors can have important impact on tumor progression and
response to therapy. We present an efficient algorithm to simultaneously estimate the …

Researchers view vast zeros in single-cell RNA-seq data differently: some regard zeros as
biological signals representing no or low gene expression, while others regard zeros as …

The emerging single-cell RNA sequencing (scRNA-seq) technologies enable the
investigation of transcriptomic landscapes at the single-cell resolution. ScRNA-seq data …

Cells from the same individual share common genetic and environmental backgrounds and
are not statistically independent; therefore, they are subsamples or pseudoreplicates. Thus …

Single-cell RNA sequencing (scRNA-seq) offers new possibilities to address biological and
medical questions. However, systematic comparisons of the performance of diverse scRNA …

Although long-read single-cell RNA isoform sequencing (scISO-Seq) can reveal alternative
RNA splicing in individual cells, it suffers from a low read throughput. Here, we introduce HIT …