Tumors are significant diseases that pose a substantial threat to human health. Presently,
there are diverse methods for diagnosing and treating tumors in clinical. However, real-time …

Motivation Recent advances in highly multiplexed imaging have provided unprecedented
insights into the complex cellular organization of tissues, with many applications in …

RNA m5C methylation has been extensively implicated in the occurrence and development
of tumors. As the main methyltransferase, NSUN2 plays a crucial regulatory role across …

Background The tumor microenvironment and intercellular communication between solid
tumors and the surrounding stroma play crucial roles in cancer initiation, progression, and …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited
treatment options, which warrants identification of novel therapeutic targets. Deciphering …

Our ability to interrogate the tumor immune microenvironment (TIME) at an ever-increasing
granularity has uncovered critical determinants of disease progression. Not only do we now …

Tissues are organized in niches where cell types interact to implement specific functions.
Spatial-omics technologies allow to decode the molecular features and spatial interactions …

Background: Cancer-associated fibroblasts (CAFs) are one of the most predominant cellular
subpopulations in the tumor stroma and play an integral role in cancer occurrence and …

Breast cancer is a highly heterogeneous disease, at both inter-and intra-tumor levels, and
this heterogeneity is a crucial determinant of malignant progression and response to …

Background Single-cell multiplex imaging data have provided new insights into disease
subtypes and prognoses recently. However, quantitative models that explicitly capture single …