Purpose: To explore the clinical significance of copper-dependent-related genes (CDRG) in
female breast cancer (BC). Methods: CDRG were obtained by single-cell analysis of the …

Simple Summary Metabolic alterations (ie, high glucose levels) enhance cancer cell
aggressiveness by acting on tumor and on its environment. Mammary adipose tissue …

Spatial profiling of tissues promises to elucidate tumor-microenvironment interactions and
enable development of spatial biomarkers to predict patient response to immunotherapy and …

Background High grade serous ovarian carcinoma (HGSC) is the most lethal gynecologic
malignancy characterized by chemoresistance and high rates of recurrence. HGSC tumors …

The tumor microenvironment is widely recognized for its central role in driving cancer
progression and influencing prognostic outcomes. Despite extensive research efforts …

The most enriched cell types in the breast tumor microenvironment are cancer cells, cancer-
associated fibroblasts, and tumor-associated macrophages. To recapitulate the cellular …

Spatial biology, which combines molecular biology and advanced imaging, enhances our
understanding of tissue cellular organisation. Despite its potential, spatial omics encounters …

Macrophages are pivotal in driving breast tumor development, progression, and resistance
to treatment, particularly in estrogen receptor-positive (ER+) tumors, where they infiltrate the …

We recently showed that lung tumor specific KRAS-G12C inhibition causes remodelling of
the tumor immune microenvironment from cold to hot. As a result, KRAS-G12C inhibition is …

Human cutaneous leishmaniasis (CL) is characterised by chronic skin pathology.
Experimental and clinical data suggest that immune checkpoints (ICs) play a crucial role in …