The development of metastasis, responsible for the majority of cancer-related fatalities, is the
most dangerous aspect of breast cancer, the predominant malignancy affecting women. We …

Living objects have complex internal and external interactions. The complexity is regulated
and controlled by homeostasis, which is the balance of multiple opposing influences. The …

Physiological and pathological processes such as inflammation or cancer emerge from the
interactions between cells over time. However, methods to follow cell populations over time …

Recent advancements in single-cell RNA sequencing (scRNA-seq) have enabled the
identification of phenotypic diversity within breast tumor tissues. However, the contribution of …

Mapping spatial interactions of cancer, immune and stromal cells present novel
opportunities for patient stratification and for advancing immunotherapy. While single-cell …

Triple-negative breast cancer (TNBC) is an aggressive subtype of breast cancer with limited
treatment options, which warrants identification of novel therapeutic targets. Deciphering …

Tissue development, function, and disease are largely driven by the spatial organization of
individual cells and their cell-cell interactions. Precision engineered tissues with single-cell …

Spatial profiling of tissues promises to elucidate tumor-microenvironment interactions and
enable development of spatial biomarkers to predict patient response to immunotherapy and …

Breast cancer is characterised by genetic and epigenetic alterations, such as G-quadruplex
(G4) DNA secondary structures. Here, we uncover differentially enriched G4 structure …

The tumor microenvironment is widely recognized for its central role in driving cancer
progression and influencing prognostic outcomes. Despite extensive research efforts …