For almost 30 years, the non-obese diabetic (NOD) mouse has served as the primary model
for dissecting the genetic and pathogenic basis for T-lymphocyte-mediated autoimmune type …

B-cells are important in the development of type 1 diabetes, but their role is not completely
defined. Although B-cells produce autoantibodies, these are not thought to be pathogenic; …

B cells have a prominent role in the pathogenesis of systemic lupus erythematosus (SLE).
They are mediators of inflammation through the production of pathogenic antibodies that …

B cells play an important role in rheumatoid arthritis, but whether they are required as
autoantibody-producing cells as well as APCs has not been determined. We assessed B cell …

Recent evidence suggests a role for B cells in the pathogenesis of young-onset type 1
diabetes (T1D), wherein rapid progression occurs. However, little is known regarding the …

It is suggested that the maternal transmission of islet autoantibodies increases the risk of
autoimmune diabetes in mice. The aim of this study was to determine whether fetal exposure …

Graves' hyperthyroidism can be induced in mice or hamsters by novel approaches, namely
injecting cells expressing the TSH receptor (TSHR) or vaccination with TSHR-DNA in …

Autoimmune diabetes occurs when invading lymphocytes destroy insulin-producing β cells
in pancreatic islets. The role of lymphocytic aggregates at this inflammatory site is not …

Autoimmune diseases with high population prevalence such as type 1 diabetes (T1D)
develop as a result of ill-defined interactions between putative environmental triggers and a …

NKT cell activation by α-galactosylceramide (α-GalCer) inhibits autoimmune diabetes in
NOD mice, in part by inducing recruitment to pancreatic lymph nodes (PLNs) of mature …