B cells are antibody (Ab)–secreting cells as well as potent antigen (Ag)–presenting cells that
prime T-cell activation, which evokes great interest in their use for vaccine development …

A large proportion of hemophilia A patients who receive replacement therapy, develop an
immune response toward the infused factor VIII (FVIII). In this review, we discuss recent …

Although B cells are crucial antigen-presenting cells in the initiation of T cell autoimmunity to
islet β cell autoantigens in type 1 diabetes (T1D), adhesion molecules that control migration …

Developing B cells undergo selection at multiple checkpoints to eliminate autoreactive
clones. We analyzed B cell kinetics in the NOD mouse to establish whether these …

Type 1 diabetes (T1D) is an autoimmune disease for which there is no cure. The pancreatic
beta cells are the source of insulin that keeps blood glucose normal. When susceptible …

B cells have been strongly implicated in the development of human type 1 diabetes and are
required for disease in the NOD mouse model. These functions are dependent on B cell …

B-cells accumulate in pancreatic islets during the autoimmune response that precedes the
onset of type 1 diabetes. However, the role and antigenic specificity of these cells remain a …

Despite the pivotal role of dendritic cells (DC) in shaping immunity, little is known about their
functionality in type 1 diabetes. Moreover, due to the paucity of DC in vivo, functional studies …

Islet autoantibodies are the primary biomarkers used to predict type 1 diabetes (T1D)
disease risk. They signal immune tolerance breach by islet autoantigen-specific B …

Mature B lymphocytes do not constitute a homogenous pool of cells, and it is now clear that
several functionally and developmentally distinct subsets exist. Of these, marginal zone (MZ) …