Postoperative cognitive dysfunction and dementia: what we need to know and do

MJ Needham, CE Webb… - BJA: British Journal of …, 2017 - academic.oup.com
Approximately 12% of apparently previously cognitively well patients undergoing
anaesthesia and noncardiac surgery will develop symptoms of cognitive dysfunction after …

The interface between delirium and dementia in elderly adults

TG Fong, D Davis, ME Growdon… - The Lancet …, 2015 - thelancet.com
Delirium and dementia are two of the most common causes of cognitive impairment in older
populations, yet their interrelation remains poorly understood. Previous studies have shown …

Hospital-level care at home for acutely ill adults: a randomized controlled trial

DM Levine, K Ouchi, B Blanchfield, A Saenz… - Annals of internal …, 2020 - acpjournals.org
Background: Substitutive hospital-level care in a patient's home may reduce cost, health
care use, and readmissions while improving patient experience, although evidence from …

The limitations of deep learning in adversarial settings

N Papernot, P McDaniel, S Jha… - 2016 IEEE European …, 2016 - ieeexplore.ieee.org
Deep learning takes advantage of large datasets and computationally efficient training
algorithms to outperform other approaches at various machine learning tasks. However …

American society for enhanced recovery and perioperative quality initiative joint consensus statement on postoperative delirium prevention

CG Hughes, CS Boncyk, DJ Culley… - Anesthesia & …, 2020 - journals.lww.com
Postoperative delirium is a geriatric syndrome that manifests as changes in cognition,
attention, and levels of consciousness after surgery. It occurs in up to 50% of patients after …

Cognitive trajectories after postoperative delirium

JS Saczynski, ER Marcantonio, L Quach… - … England Journal of …, 2012 - Mass Medical Soc
Background Delirium is common after cardiac surgery and may be associated with long-term
changes in cognitive function. We examined postoperative delirium and the cognitive …

Neuropathogenesis of delirium: review of current etiologic theories and common pathways

JR Maldonado - The American Journal of Geriatric Psychiatry, 2013 - Elsevier
Delirium is a neurobehavioral syndrome caused by dysregulation of neuronal activity
secondary to systemic disturbances. Over time, a number of theories have been proposed in …

Prevention and management of delirium in the intensive care unit

MF Mart, SW Roberson, B Salas… - … in respiratory and …, 2021 - thieme-connect.com
Delirium is a debilitating form of brain dysfunction frequently encountered in the intensive
care unit (ICU). It is associated with increased morbidity and mortality, longer lengths of stay …

Microglia in neurodegenerative disease

VH Perry, JAR Nicoll, C Holmes - Nature Reviews Neurology, 2010 - nature.com
Microglia, the resident macrophages of the CNS, are exquisitely sensitive to brain injury and
disease, altering their morphology and phenotype to adopt a so-called activated state in …

The anatomy and physiology of normal and abnormal swallowing in oropharyngeal dysphagia

A Sasegbon, S Hamdy - Neurogastroenterology & Motility, 2017 - Wiley Online Library
Background Eating and drinking are enjoyable activities that positively impact on an
individual's quality of life. The ability to swallow food and fluid is integral to the process of …