The science of large-scale brain networks offers a powerful paradigm for investigating
cognitive and affective dysfunction in psychiatric and neurological disorders. This review …

Insula function is considered critical for many motivated behaviors, with proposed functions
ranging from attention, behavioral control, emotional regulation, goal-directed and aversion …

This chapter begins with a summary of the initial findings on the effects of insula lesions on
smoking behavior as well as more recent human‐lesion studies that replicate and extend …

Brain lesions that damage the insular cortex (IC) interrupt addictive behaviors, suggesting
that drug addiction sensitizes the insula. However, neuroimaging studies seem to lead to an …

The role of interoception and its neural basis with relevance to drug addiction is reviewed.
Interoception consists of the receiving, processing, and integrating body-relevant signals …

Substance use disorders (SUDs) are a growing public health concern with only a limited
number of approved treatments. However, even approved treatments are subject to limited …

Background The impact of prenatal opioid exposure on brain development remains poorly
understood. Methods We conducted a prospective study of term-born infants with and …

Smokers have substantial individual differences in quit success in response to current
treatments for nicotine dependence. This observation may suggest that different underlying …

Neuroimaging studies on cue reactivity have substantially contributed to the understanding
of addiction. In the majority of studies drug cues were presented in the visual modality …

The anterior insular cortex plays a key role in the representation of interoceptive effects of
drug and natural rewards and their integration with attention, executive function, and …