Exosomes based strategies for brain drug delivery

FU Rehman, Y Liu, M Zheng, B Shi - Biomaterials, 2023 - Elsevier
Exosome application has emerged as a promising nanotechnology discipline for various
diseases therapeutics and diagnoses. Owing to the natural properties of efficient drug …

Extracellular vesicles in cancer—implications for future improvements in cancer care

R Xu, A Rai, M Chen, W Suwakulsiri… - Nature reviews Clinical …, 2018 - nature.com
The sustained growth, invasion, and metastasis of cancer cells depend upon bidirectional
cell–cell communication within complex tissue environments. Such communication …

Organelle-level precision with next-generation targeting technologies

A Saminathan, M Zajac, P Anees… - Nature Reviews Materials, 2022 - nature.com
Intracellular organelles are subsystems within a cell, whose activity and chemical
composition reflect the metabolic state of live cells. Alterations in cellular homeostasis …

[HTML][HTML] Engineering nano-drug biointerface to overcome biological barriers toward precision drug delivery

S Waheed, Z Li, F Zhang, A Chiarini, U Armato… - Journal of …, 2022 - Springer
The rapid advancement of nanomedicine and nanoparticle (NP) materials presents novel
solutions potentially capable of revolutionizing health care by improving efficacy …

[HTML][HTML] Recent advancements in the use of exosomes as drug delivery systems

EJ Bunggulawa, W Wang, T Yin, N Wang… - Journal of …, 2018 - Springer
Extracellular vesicles (EVs) are the substances that are released by most types of cells and
have an important role in cell to cell communication. Among the most highly researched EVs …

[HTML][HTML] Challenges and opportunities in exosome research—Perspectives from biology, engineering, and cancer therapy

X Li, AL Corbett, E Taatizadeh, N Tasnim, JP Little… - APL …, 2019 - pubs.aip.org
ABSTRACT Exosomes are small ($30–140 nm) lipid bilayer-enclosed particles of
endosomal origin. They are a subset of extracellular vesicles (EVs) that are secreted by most …

Recent advances in overcoming barriers to cell‐based delivery systems for cancer immunotherapy

Y Ding, Y Wang, Q Hu - Exploration, 2022 - Wiley Online Library
Immunotherapy strategies that use cell‐based delivery systems have sparked much interest
in the treatment of malignancies, owing to their high biocompatibility, excellent tumor …

Potential use of exosomes as diagnostic biomarkers and in targeted drug delivery: progress in clinical and preclinical applications

MN Huda, M Nafiujjaman, IG Deaguero… - ACS biomaterials …, 2021 - ACS Publications
Exosomes are cell-derived vesicles containing heterogeneous active biomolecules such as
proteins, lipids, mRNAs, receptors, immune regulatory molecules, and nucleic acids. They …

[HTML][HTML] Biodistribution of exosomes and engineering strategies for targeted delivery of therapeutic exosomes

H Choi, Y Choi, HY Yim, A Mirzaaghasi, JK Yoo… - Tissue engineering and …, 2021 - Springer
Exosomes are cell-secreted nano-sized vesicles which deliver diverse biological molecules
for intercellular communication. Due to their therapeutic potential, exosomes have been …

[HTML][HTML] Isolation of cabbage exosome-like nanovesicles and investigation of their biological activities in human cells

JY You, SJ Kang, WJ Rhee - Bioactive materials, 2021 - Elsevier
There are extensive studies on the applications of extracellular vesicles (EVs) produced in
cell culture for therapeutic drug development. However, large quantities of EVs are needed …