[PDF][PDF] Artificial intelligence for proteomics and biomarker discovery

M Mann, C Kumar, WF Zeng, MT Strauss - Cell systems, 2021 - cell.com
There is an avalanche of biomedical data generation and a parallel expansion in
computational capabilities to analyze and make sense of these data. Starting with genome …

Advances in data‐independent acquisition mass spectrometry towards comprehensive digital proteome landscape

RB Kitata, JC Yang, YJ Chen - Mass spectrometry reviews, 2023 - Wiley Online Library
The data‐independent acquisition mass spectrometry (DIA‐MS) has rapidly evolved as a
powerful alternative for highly reproducible proteome profiling with a unique strength of …

[PDF][PDF] Proteome profiling of cerebrospinal fluid reveals biomarker candidates for Parkinson's disease

O Karayel, SV Winter, S Padmanabhan, YI Kuras… - Cell Reports …, 2022 - cell.com
Parkinson's disease (PD) is a growing burden worldwide, and there is no reliable biomarker
used in clinical routines to date. Cerebrospinal fluid (CSF) is routinely collected in patients …

[PDF][PDF] Proteomic and metabolomic profiling of urine uncovers immune responses in patients with COVID-19

X Bi, W Liu, X Ding, S Liang, Y Zheng, X Zhu, S Quan… - Cell reports, 2022 - cell.com
The utility of the urinary proteome in infectious diseases remains unclear. Here, we analyzed
the proteome and metabolome of urine and serum samples from patients with COVID-19 …

Mass spectrometry‐based high‐throughput proteomics and its role in biomedical studies and systems biology

CB Messner, V Demichev, Z Wang, J Hartl… - …, 2023 - Wiley Online Library
There are multiple reasons why the next generation of biological and medical studies
require increasing numbers of samples. Biological systems are dynamic, and the effect of a …

High-throughput proteomics and AI for cancer biomarker discovery

Q Xiao, F Zhang, L Xu, L Yue, OL Kon, Y Zhu… - Advanced drug delivery …, 2021 - Elsevier
Biomarkers are assayed to assess biological and pathological status. Recent advances in
high-throughput proteomic technology provide opportunities for developing next generation …

Perspective on the current state of the LRRK2 field

JM Taymans, M Fell, T Greenamyre, WD Hirst… - npj Parkinson's …, 2023 - nature.com
Almost 2 decades after linking LRRK2 to Parkinson's disease, a vibrant research field has
developed around the study of this gene and its protein product. Recent studies have begun …

Proteomics of human biological fluids for biomarker discoveries: technical advances and recent applications

L Dayon, O Cominetti, M Affolter - Expert review of proteomics, 2022 - Taylor & Francis
Introduction Biological fluids are routine samples for diagnostic testing and monitoring.
Blood samples are typically measured because of their moderate invasive collection and …

Proteomic discovery of non-invasive biomarkers of localized prostate cancer using mass spectrometry

A Khoo, LY Liu, JO Nyalwidhe, OJ Semmes… - Nature Reviews …, 2021 - nature.com
Prostate cancer is the second most frequently diagnosed non-skin cancer in men worldwide.
Patient outcomes are remarkably heterogeneous and the best existing clinical prognostic …

Advances in proteomic and metabolomic profiling of neurodegenerative diseases

A Schumacher-Schuh, A Bieger, WV Borelli… - Frontiers in …, 2022 - frontiersin.org
Proteomics and metabolomics are two emerging fields that hold promise to shine light on the
molecular mechanisms causing neurodegenerative diseases. Research in this area may …