DNA is an intelligent data storage medium due to its stability and high density. It has been
used by nature for over 3.5 billion years. Compared with traditional methods, DNA offers …

Genetic mutation, which provides the raw material for evolutionary adaptation, is largely a
stochastic force. However, there is ample evidence showing that mutations can also exhibit …

Antibiotic resistance (AMR) is an alarming concern worldwide and Helicobacter pylori, one
of the most prevalent bacteria, is not an exception. With antibiotics being its primary therapy …

Candida auris has become a serious threat to public health. The mechanisms of how this
fungal pathogen adapts to the mammalian host are poorly understood. Here we report the …

The existence of an environmentally regulated version of meiotic crossing-over, or eco-
crossover, is proposed, and the main consequences of this hypothesis are considered. Eco …

The ecological and evolutionary mechanisms of antimicrobial resistance (AMR) emergence
within patients and how these vary across bacterial infections are poorly understood …

The mortality rates of invasive fungal infections remain high because of the limited number
of antifungal drugs available and antifungal drug resistance, which can rapidly evolve during …

Aim Fluoroquinolone (FQ) is a potent antibiotic class. However, resistance to this class
emerges quickly which hinders its application. In this study, mechanisms leading to the …

Targeted hypermutation has proven to be a useful survival strategy for bacteria under severe
stress and is also used by multicellular organisms in specific instances such as the …

Neisseria gonorrhoeae (a Gram-negative diplococcus) is a human pathogen and causative
agent of gonorrhea, a sexually transmitted infection. The bacterium uses various …