Deubiquitinase inhibitor PR‐619 potentiates colon cancer immunotherapy by inducing ferroptosis
J Wu, C Liu, T Wang, H Liu, B Wei - Immunology, 2023 - Wiley Online Library
A substantial number of colon cancer patients do not benefit from immunotherapy using
programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are …
programmed cell death 1 (PD1) antibodies. Therefore, combination therapy drugs are …
Degrasyn alleviates osteoarthritis by blocking macrophagic pyroptosis via suppressing NLRP3/GSDMD signaling pathway and protecting chondrocytes
S Xie, L Wang, C Lu, H Chen, Y Ding, X Jian, Z Zhang… - Cellular …, 2024 - Elsevier
Synovitis and cartilage destruction are crucial characteristics of osteoarthritis (OA).
Inflammatory cytokines, such as IL-1β, are secreted by synovial macrophages, leading to …
Inflammatory cytokines, such as IL-1β, are secreted by synovial macrophages, leading to …
Native mass spectrometry reveals binding interactions of SARS-CoV-2 PLpro with inhibitors and ISG15
Here we used native mass spectrometry (native MS) to probe a SARS-CoV protease, PLpro,
which plays critical roles in coronavirus disease by affecting viral protein production and …
which plays critical roles in coronavirus disease by affecting viral protein production and …