[HTML][HTML] Noradrenergic and cholinergic systems take centre stage in neuropsychiatric diseases of ageing
Noradrenergic and cholinergic systems are among the most vulnerable brain systems in
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …
neuropsychiatric diseases of ageing, including Alzheimer's disease, Parkinson's disease …
Application of neuromelanin MR imaging in Parkinson disease
MRI has been used to develop biomarkers for movement disorders such as Parkinson
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …
disease (PD) and other neurodegenerative disorders with parkinsonism such as progressive …
The noradrenergic subtype of Parkinson disease: from animal models to clinical practice
K Ray Chaudhuri, V Leta, K Bannister… - Nature Reviews …, 2023 - nature.com
Many advances in understanding the pathophysiology of Parkinson disease (PD) have been
based on research addressing its motor symptoms and phenotypes. Various data-driven …
based on research addressing its motor symptoms and phenotypes. Various data-driven …
Morphological basis of Parkinson disease-associated cognitive impairment: an update
KA Jellinger - Journal of Neural Transmission, 2022 - Springer
Cognitive impairment is one of the most salient non-motor symptoms of Parkinson disease
(PD) that poses a significant burden on the patients and carers as well as being a risk factor …
(PD) that poses a significant burden on the patients and carers as well as being a risk factor …
Locus Coeruleus Integrity Is Linked to Response Inhibition Deficits in Parkinson's Disease and Progressive Supranuclear Palsy
Parkinson's disease (PD) and progressive supranuclear palsy (PSP) both impair response
inhibition, exacerbating impulsivity. Inhibitory control deficits vary across individuals and are …
inhibition, exacerbating impulsivity. Inhibitory control deficits vary across individuals and are …
Apathy in Parkinson's disease: Clinical patterns and neurobiological basis
Apathy is commonly defined as a loss of motivation leading to a reduction in goal-directed
behaviors. This multidimensional syndrome, which includes cognitive, emotional and …
behaviors. This multidimensional syndrome, which includes cognitive, emotional and …
Noradrenergic alterations in Parkinson's disease: a combined 11C-yohimbine PET/neuromelanin MRI study
Degeneration of the noradrenergic system is now considered a pathological hallmark of
Parkinson's disease, but little is known about its consequences in terms of parkinsonian …
Parkinson's disease, but little is known about its consequences in terms of parkinsonian …
Noradrenergic neuromodulation in ageing and disease
F Krohn, E Lancini, M Ludwig, M Leiman… - Neuroscience & …, 2023 - Elsevier
The locus coeruleus (LC) is a small brainstem structure located in the lower pons and is the
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
main source of noradrenaline (NA) in the brain. Via its phasic and tonic firing, it modulates …
Age-dependent dysregulation of locus coeruleus firing in a transgenic rat model of Alzheimer's disease
MA Kelberman, JM Rorabaugh, CR Anderson… - Neurobiology of …, 2023 - Elsevier
Hyperphosphorylated tau in the locus coeruleus (LC) is ubiquitous in prodromal Alzheimer's
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …
disease (AD), and LC neurons degenerate as AD progresses. Hyperphosphorylated tau …
Impaired value-based decision-making in Parkinson's disease apathy
W Gilmour, G Mackenzie, M Feile, L Tayler-Grint… - Brain, 2024 - academic.oup.com
Apathy is a common and disabling complication of Parkinson's disease characterized by
reduced goal-directed behaviour. Several studies have reported dysfunction within …
reduced goal-directed behaviour. Several studies have reported dysfunction within …