Lacunar infarcts and vascular dementia are important phenotypic characteristics of cerebral
autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy, the …

Cerebral microvascular disease (MVD) is an important cause of vascular cognitive
impairment. MVD is heterogeneous in aetiology, ranging from universal ageing to the …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is a cerebral small vessel disease that carries mutations in …

Loss of arterial smooth muscle cells (SMCs) and abnormal accumulation of the extracellular
domain of the NOTCH3 receptor (Notch3ECD) are the 2 core features of CADASIL, a …

Background Cerebral autosomal dominant arteriopathy with subcortical infarcts and
leukoencephalopathy (CADASIL) is the most common hereditary cerebral small vessel …

Cerebral small vessel disease (CSVD) includes various entities affecting the brain and,
often, systemic small arteries, arterioles, venules, and capillaries. The underlying causes of …

Notch signaling is conserved in C. elegans, Drosophila, and mammals. Among the four
NOTCH genes in humans, NOTCH1, NOTCH2, and NOTCH3 are known to cause …

Stroke is an important disease with unmet clinical need. To uncover novel paths for
treatment, it is of critical importance to develop relevant laboratory models that may help to …

Objectives: Summarize the pathophysiology of lacunar stroke. Review history and physical
examination findings of patients suffering from lacunar infarctions. Outline various treatment …

Cerebral small vessel disease is a neurological disease that affects the brain
microvasculature and which is commonly observed among the elderly. Although at first it …