Tightly orchestrated programmed cell death (PCD) signalling events occur during normal
neuronal development in a spatially and temporally restricted manner to establish the neural …

Ferroptosis, a programmed cell death, has been identified and associated with cancer and
various other diseases. Ferroptosis is defined as a reactive oxygen species (ROS) …

Epithelial-mesenchymal transition (EMT) and Cancer stem-like cells (CSCs) are major
factors contributing to the metastasis of cancer cells. Consequently, the signaling pathways …

Metastasis is the hallmark of cancer that is responsible for the greatest number of cancer-
related deaths. Yet, it remains poorly understood. The continuous evolution of cancer …

Skeletal metastases are frequent complications of many cancers, causing bone
complications (fractures, bone pain, disability) that negatively affect the patient's quality of …

Metastasis is the primary cause of cancer morbidity and mortality. The process involves a
complex interplay between intrinsic tumor cell properties as well as interactions between …

Abstract Hypoxia‐inducible factor 1 (HIF‐1) plays an indispensable role in the hypoxic tumor
microenvironment. Hypoxia and HIF‐1 are involved in multiple aspects of tumor progression …

During tumorigenesis, cancer cells are exposed to a wide variety of intrinsic and extrinsic
stresses that challenge homeostasis and growth. Cancer cells display activation of distinct …

Cancer cells continuously rewire their metabolism to fulfill their need for rapid growth and
survival while subject to changes in environmental cues. Thus, a vital component of a cancer …

Anchorage-independent survival of cancer cells is associated with metastasis as it enables
cells to travel to secondary target sites. Tissue integrity is generally maintained by …