[HTML][HTML] Oxidative stress and inflammation in osteoarthritis pathogenesis: Role of polyphenols

MY Ansari, N Ahmad, TM Haqqi - Biomedicine & pharmacotherapy, 2020 - Elsevier
Osteoarthritis (OA) is the most prevalent joint degenerative disease leading to irreversible
structural and functional changes in the joint and is a major cause of disability and reduced …

Disease-modifying therapeutic strategies in osteoarthritis: current status and future directions

Y Cho, S Jeong, H Kim, D Kang, J Lee… - … & molecular medicine, 2021 - nature.com
Osteoarthritis (OA) is the most common form of arthritis. It is characterized by progressive
destruction of articular cartilage and the development of chronic pain and constitutes a …

NF-κB signaling pathways in osteoarthritic cartilage destruction

MC Choi, J Jo, J Park, HK Kang, Y Park - Cells, 2019 - mdpi.com
Osteoarthritis (OA) is a type of joint disease associated with wear and tear, inflammation,
and aging. Mechanical stress along with synovial inflammation promotes the degradation of …

[HTML][HTML] ROS/oxidative stress signaling in osteoarthritis

P Lepetsos, AG Papavassiliou - … et Biophysica Acta (BBA)-Molecular Basis …, 2016 - Elsevier
Osteoarthritis is the most common joint disorder with increasing prevalence due to aging of
the population. Its multi-factorial etiology includes oxidative stress and the overproduction of …

Redox and NF-κB signaling in osteoarthritis

P Lepetsos, KA Papavassiliou… - Free Radical Biology and …, 2019 - Elsevier
Human cells have to deal with the constant production of reactive oxygen species (ROS).
Although ROS overproduction might be harmful to cell biology, there are plenty of data …

Role of chondrocytes in cartilage formation, progression of osteoarthritis and cartilage regeneration

H Akkiraju, A Nohe - Journal of developmental biology, 2015 - mdpi.com
Articular cartilage (AC) covers the diarthrodial joints and is responsible for the mechanical
distribution of loads across the joints. The majority of its structure and function is controlled …

Reciprocal inhibition of YAP/TAZ and NF-κB regulates osteoarthritic cartilage degradation

Y Deng, J Lu, W Li, A Wu, X Zhang, W Tong… - Nature …, 2018 - nature.com
Osteoarthritis is one of the leading causes of pain and disability in the aged population due
to articular cartilage damage. This warrants investigation of signaling mechanisms that could …

[HTML][HTML] Microvesicles from human adipose tissue-derived mesenchymal stem cells as a new protective strategy in osteoarthritic chondrocytes

M Tofiño-Vian, MI Guillén, MD Pérez del Caz… - Cellular Physiology and …, 2018 - karger.com
Background/Aims: Chronic inflammation contributes to cartilage degeneration during the
progression of osteoarthritis (OA). Adipose tissue-derived mesenchymal stem cells (AD …

[HTML][HTML] Call for standardized definitions of osteoarthritis and risk stratification for clinical trials and clinical use

VB Kraus, FJ Blanco, M Englund, MA Karsdal… - Osteoarthritis and …, 2015 - Elsevier
Osteoarthritis (OA) is a heterogeneous disorder. The goals of this review are (1) To stimulate
use of standardized nomenclature for OA that could serve as building blocks for describing …

Curcumin reinforces MSC‐derived exosomes in attenuating osteoarthritis via modulating the miR‐124/NF‐kB and miR‐143/ROCK1/TLR9 signalling pathways

B Qiu, X Xu, P Yi, Y Hao - Journal of Cellular and Molecular …, 2020 - Wiley Online Library
Curcumin treatment was reported to delay the progression of OA, but its underlying
mechanism remains unclear. In this study, we aimed to investigate the molecular …