HOTAIR: a potential metastatic, drug-resistant and prognostic regulator of breast cancer

GSR Raju, E Pavitra, SS Bandaru, GL Varaprasad… - Molecular cancer, 2023 - Springer
HOX transcript antisense intergenic RNA (HOTAIR) is an oncogenic non-coding RNA whose
expression is strongly correlated with the tumor grade and prognosis of a variety of …

HOX transcript antisense RNA (HOTAIR) in cancer

X Qu, S Alsager, Y Zhuo, B Shan - Cancer letters, 2019 - Elsevier
Long noncoding RNAs (lncRNAs) have emerged as a new family of master regulators of
cancer. The lncRNA HOX transcript antisense RNA (HOTAIR) is a prime example of an …

Homeobox genes in cancers: from carcinogenesis to recent therapeutic intervention

Y Feng, T Zhang, Y Wang, M Xie, X Ji, X Luo… - Frontiers in …, 2021 - frontiersin.org
The homeobox (HOX) genes encoding an evolutionarily highly conserved family of
homeodomain-containing transcriptional factors are essential for embryogenesis and …

Glycoprotein PTGDS promotes tumorigenesis of diffuse large B-cell lymphoma by MYH9-mediated regulation of Wnt–β-catenin–STAT3 signaling

S Hu, S Ren, Y Cai, J Liu, Y Han, Y Zhao… - Cell Death & …, 2022 - nature.com
Glycoprotein prostaglandin D2 synthase (PTGDS) is a member of the lipocalin superfamily
and plays dual roles in prostaglandins metabolism and lipid transport. PTGDS has been …

The role of LncRNAs in tumor immunotherapy

X Pan, C Li, J Feng - Cancer cell international, 2023 - Springer
Cancer immunotherapy is a major breakthrough in the history of tumor therapy in the last
decade. Immune checkpoint inhibitors blocking CTLA-4/B7 or PD-1/PD-L1 pathways have …

[HTML][HTML] EZH2, a prominent orchestrator of genetic and epigenetic regulation of solid tumor microenvironment and immunotherapy

S Sun, F Yu, D Xu, H Zheng, M Li - … et Biophysica Acta (BBA)-Reviews on …, 2022 - Elsevier
Immune checkpoint blockade (ICB) is regarded as a promising strategy for cancer therapy.
The histone methyltransferase, Enhancer of Zeste Homolog 2 (EZH2), has been implicated …

Dual relationship between long non-coding RNAs and STAT3 signaling in different cancers: New insight to proliferation and metastasis

M Ashrafizadeh, MH Gholami, S Mirzaei, A Zabolian… - Life sciences, 2021 - Elsevier
Uncontrolled growth and metastasis of cancer cells is an increasing challenge for
overcoming cancer, and improving survival of patients. Complicated signaling networks …

EZH2 abnormalities in lymphoid malignancies: underlying mechanisms and therapeutic implications

B Li, WJ Chng - Journal of Hematology & Oncology, 2019 - Springer
EZH2 is the catalytic subunit of the polycomb repressive complex 2 (PRC2), which along
with other PRC2 components mediates gene expression suppression via the methylation of …

[HTML][HTML] PD-L2 glycosylation promotes immune evasion and predicts anti-EGFR efficacy

Y Xu, Z Gao, R Hu, Y Wang, Y Wang, Z Su… - … for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
Background Combination therapy has been explored for advanced head and neck
squamous cell carcinoma (HNSCC) owing to the limited efficacy of anti-epidermal growth …

RNA-based liquid biopsy in head and neck cancer

J Kabzinski, A Kucharska-Lusina, I Majsterek - Cells, 2023 - mdpi.com
Head and neck cancer (HNC) is a prevalent and diverse group of malignancies with
substantial morbidity and mortality rates. Early detection and monitoring of HNC are crucial …