As diabetes rates surge globally, there is a corresponding rise in the number of patients
suffering from diabetic kidney disease (DKD), a common complication of diabetes. DKD is a …

Mitochondria play a key role in kidney physiology and pathology. They produce ATP to fuel
energy-demanding water and solute reabsorption processes along the nephron. Moreover …

Early diabetic kidney disease (DKD) is marked by dramatic metabolic reprogramming due to
nutrient excess, mitochondrial dysfunction, and increased renal energy requirements from …

Podocyte injury is involved in the onset and progression of diabetic kidney disease (DKD)
and is associated with mitochondrial abnormalities. Defective mitochondrial DNA (mtDNA) …

While it is generally accepted that oxidative stress impacts the diabetic kidney and
contributes to pathogenesis, there is a substantial lack of knowledge about the molecular …

db/db mice, which lack leptin receptors and exhibit hyperphagia, show disturbances in
energy metabolism and are a model of obesity and type 2 diabetes. The geroneuroprotector …

Diabetic kidney disease (DKD), has become the main cause of end-stage renal disease
(ESRD) worldwide. Lately, it has been shown that the onset and advancement of DKD are …

Hyperglycemia can also induce the production of free radicals and the progression of
inflammatory reactions. The aim of this study is to explore the potential anti-oxidant and anti …

Tetrahydrocurcumin (THC), a principal metabolite of curcumin, was tested in a rat model of
type 2 diabetes mellitus. THC was administered via daily oral gavage with the lipid carrier …

Background Perturbed mitochondrial energetics and vitamin A (VitA) metabolism are
associated with the pathogenesis of diet-induced obesity (DIO) and type 2 diabetes (T2D) …