Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …

The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …

Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …

Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …

The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …

Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …

Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …

Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …

Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …

As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …