[HTML][HTML] Wound healing, fibroblast heterogeneity, and fibrosis
Fibroblasts are highly dynamic cells that play a central role in tissue repair and fibrosis.
However, the mechanisms by which they contribute to both physiologic and pathologic …
However, the mechanisms by which they contribute to both physiologic and pathologic …
Chromatin accessibility profiling by ATAC-seq
The assay for transposase-accessible chromatin using sequencing (ATAC-seq) provides a
simple and scalable way to detect the unique chromatin landscape associated with a cell …
simple and scalable way to detect the unique chromatin landscape associated with a cell …
[HTML][HTML] Fibroblasts: Origins, definitions, and functions in health and disease
Fibroblasts are diverse mesenchymal cells that participate in tissue homeostasis and
disease by producing complex extracellular matrix and creating signaling niches through …
disease by producing complex extracellular matrix and creating signaling niches through …
Cancer stem cell–immune cell crosstalk in tumour progression
Cellular heterogeneity and an immunosuppressive tumour microenvironment are
independent yet synergistic drivers of tumour progression and underlie therapeutic …
independent yet synergistic drivers of tumour progression and underlie therapeutic …
[HTML][HTML] Trained immunity, tolerance, priming and differentiation: distinct immunological processes
The similarities and differences between trained immunity and other immune processes are
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
the subject of intense interrogation. Therefore, a consensus on the definition of trained …
[HTML][HTML] Hallmarks of health
C López-Otín, G Kroemer - Cell, 2021 - cell.com
Health is usually defined as the absence of pathology. Here, we endeavor to define health
as a compendium of organizational and dynamic features that maintain physiology. The …
as a compendium of organizational and dynamic features that maintain physiology. The …
[HTML][HTML] Defining trained immunity and its role in health and disease
Immune memory is a defining feature of the acquired immune system, but activation of the
innate immune system can also result in enhanced responsiveness to subsequent triggers …
innate immune system can also result in enhanced responsiveness to subsequent triggers …
Interleukin-17 governs hypoxic adaptation of injured epithelium
Mammalian cells autonomously activate hypoxia-inducible transcription factors (HIFs) to
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …
ensure survival in low-oxygen environments. We report here that injury-induced hypoxia is …
Inflammatory memory and tissue adaptation in sickness and in health
S Naik, E Fuchs - Nature, 2022 - nature.com
Our body has a remarkable ability to remember its past encounters with allergens,
pathogens, wounds and irritants, and to react more quickly to the next experience. This …
pathogens, wounds and irritants, and to react more quickly to the next experience. This …
[HTML][HTML] The immune functions of keratinocytes in skin wound healing
As the most dominant cell type in the skin, keratinocytes play critical roles in wound repair
not only as structural cells but also exerting important immune functions. This review focuses …
not only as structural cells but also exerting important immune functions. This review focuses …