Muscle cell‐derived cytokines in skeletal muscle regeneration
Regeneration of the mammalian adult skeletal muscle is a well‐orchestrated process
regulated by multiple proteins and signalling pathways. Cytokines constitute a major class of …
regulated by multiple proteins and signalling pathways. Cytokines constitute a major class of …
Neuroprotection through G-CSF: recent advances and future viewpoints
Granulocyte-colony stimulating factor (G-CSF), a member of the cytokine family of
hematopoietic growth factors, is 19.6 kDa glycoprotein which is responsible for the …
hematopoietic growth factors, is 19.6 kDa glycoprotein which is responsible for the …
Golodirsen for Duchenne muscular dystrophy.
Duchenne muscular dystrophy (DMD) is a life-shortening X-linked genetic disorder
characterized by progressive wasting and weakening of muscles in boys. Loss-of-function …
characterized by progressive wasting and weakening of muscles in boys. Loss-of-function …
Myogenesis modelled by human pluripotent stem cells: a multi‐omic study of Duchenne myopathy early onset
V Mournetas, E Massouridès, JB Dupont… - Journal of cachexia …, 2021 - Wiley Online Library
Background Duchenne muscular dystrophy (DMD) causes severe disability of children and
death of young men, with an incidence of approximately 1/5000 male births. Symptoms …
death of young men, with an incidence of approximately 1/5000 male births. Symptoms …
Applying genome-wide CRISPR-Cas9 screens for therapeutic discovery in facioscapulohumeral muscular dystrophy
The emergence of CRISPR-Cas9 gene-editing technologies and genome-wide CRISPR-
Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process …
Cas9 libraries enables efficient unbiased genetic screening that can accelerate the process …
Update on muscular dystrophies with focus on novel treatments and biomarkers
N Datta, PS Ghosh - Current neurology and neuroscience reports, 2020 - Springer
Abstract Purpose of Review Muscular dystrophies are a heterogeneous group of inherited
muscular disorders characterized by progressive muscle weakness and in many cases …
muscular disorders characterized by progressive muscle weakness and in many cases …
In vivo non-invasive monitoring of dystrophin correction in a new Duchenne muscular dystrophy reporter mouse
Duchenne muscular dystrophy (DMD) is a fatal genetic disorder caused by mutations in the
dystrophin gene. To enable the non-invasive analysis of DMD gene correction strategies in …
dystrophin gene. To enable the non-invasive analysis of DMD gene correction strategies in …
TAK1 inhibition improves myoblast differentiation and alleviates fibrosis in a mouse model of Duchenne muscular dystrophy
D Xu, S Li, L Wang, J Jiang, L Zhao… - Journal of cachexia …, 2021 - Wiley Online Library
Background Transforming growth factor‐β‐activated kinase 1 (TAK1) plays a key role in
regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 …
regulating fibroblast and myoblast proliferation and differentiation. However, the TAK1 …
A novel chemical-combination screen in zebrafish identifies epigenetic small molecule candidates for the treatment of Duchenne muscular dystrophy
Background Duchenne muscular dystrophy (DMD) is a severe neuromuscular disorder and
is one of the most common muscular dystrophies. There are currently few effective therapies …
is one of the most common muscular dystrophies. There are currently few effective therapies …
Polymeric nanoparticles functionalized with muscle-homing peptides for targeted delivery of phosphatase and tensin homolog inhibitor to skeletal muscle
Phosphatase and tensin homolog (PTEN) antagonizes muscle growth and repair, and
inhibition of PTEN has been shown to improve the pathophysiology and dystrophic muscle …
inhibition of PTEN has been shown to improve the pathophysiology and dystrophic muscle …