Tumors are comprised of both cancer cells and surrounding stromal components. As an
essential part of the tumor microenvironment, the tumor stroma is highly dynamic …

Proteoglycans (PGs) represent a large proportion of the components that constitute the
extracellular matrix (ECM). They are a diverse group of glycoproteins characterized by a …

Endometriosis is a condition that is influenced by hormones and involves stroma and glands
being found outside the uterus; there are increases in proliferation, invasion, internal …

Hepatocyte growth factor (HGF)/mesenchymal-epithelial transition factor (c-MET) signaling
is involved in complex cellular programs that are important for embryonic development and …

The tumor microenvironment (TME) has become the focus of interest in cancer research and
treatment. It includes the extracellular matrix (ECM) and ECM-modifying enzymes that are …

Melanoma is one of the most severe cancerous diseases. The cells employ multiple
signaling pathways, such as ERK, HGF/c-MET, WNT, and COX-2 to cause the cell …

Simple Summary The tumour microenvironment is composed of multiple non-cancerous
cells that communicate with the tumour cells, influencing their behaviour and impacting the …

Cell surface receptors are important proteins that mediate communication between the cells
and their outside environment, and also play essential roles in the control of a wide variety of …

Simple Summary Increasing evidence suggests that bacterial infection not only promotes
carcinogenesis in primary colorectal cancer, but also affects metastatic progression and …

Clear cell renal cell carcinoma (ccRCC) is the seventh most frequently diagnosed tumor in
adults in Europe and represents approximately 2.5% of cancer deaths. The molecular …