The last few decades have led to an explosion in our understanding of the major roles that
small regulatory RNAs (sRNAs) play in regulatory circuits and the responses to stress in …

In the ancient anaerobic environment, ferrous iron (Fe2+) was one of the first metal
cofactors. Oxygenation of the ancient world challenged bacteria to acquire the insoluble …

Iron is an essential micronutrient, and, in the case of bacteria, its availability is commonly a
growth-limiting factor. However, correct functioning of cells requires that the labile pool of …

Microorganisms play a dominant role in the biogeochemical cycling of nutrients. They are
rightly praised for their facility for fixing both carbon and nitrogen into organic matter, and …

An increasing number of small RNAs (sRNAs) have been shown to regulate critical
pathways in prokaryotes and eukaryotes. In bacteria, regulation by trans-encoded sRNAs is …

Many bacterial regulatory small RNAs (sRNAs) have several mRNA targets, which places
them at the centre of regulatory networks that help bacteria to adapt to environmental …

Iron is one of the most important metals in the metabolism of many organisms, including
bacteria, in which it serves as a cofactor in multiple enzymatic reactions. Most of the earlier …

RyhB is a small RNA (sRNA) that downregulates about 20 genes involved in iron
metabolism. It is expressed under low iron conditions and pairs with specific mRNAs to …

The emergence of pathogenic strains of enteric bacteria and their adaptation to unique
niches are associated with the acquisition of foreign DNA segments termed 'genetic islands' …

Recent studies have uncovered dozens of regulatory small RNAs in bacteria. A large
number of these small RNAs act by pairingto their target mRNAs. The outcome of pairing …