Delivering drugs to tubular cells and organelles: the application of nanodrugs in acute kidney injury

Z Li, X Fan, J Fan, W Zhang, J Liu, B Liu, H Zhang - Nanomedicine, 2023 - Taylor & Francis
Acute kidney injury (AKI) is a common clinical syndrome with limited treatment options and
high mortality rates. Proximal tubular epithelial cells (PTECs) play a key role in AKI …

Physiological principles underlying the kidney targeting of renal nanomedicines

Y Huang, X Ning, S Ahrari, Q Cai, N Rajora… - Nature Reviews …, 2024 - nature.com
Kidney disease affects more than 10% of the global population and is associated with
considerable morbidity and mortality, highlighting a need for new therapeutic options …

Clustered cobalt nanodots initiate ferroptosis by upregulating heme oxygenase 1 for radiotherapy sensitization

J Zhao, Y Chen, T Xiong, S Han, C Li, Y He, Y He… - Small, 2023 - Wiley Online Library
High cobalt (Co) levels in tumors are associated with good clinical prognosis. An anticancer
regimen that increases intratumoral Co through targeted nanomaterial delivery is proposed …

Autophagy of OTUD5 destabilizes GPX4 to confer ferroptosis-dependent kidney injury

LK Chu, X Cao, L Wan, Q Diao, Y Zhu, Y Kan… - Nature …, 2023 - nature.com
Ferroptosis is an iron-dependent programmed cell death associated with severe kidney
diseases, linked to decreased glutathione peroxidase 4 (GPX4). However, the spatial …

[HTML][HTML] Injectable hydrogel with selenium nanoparticles delivery for sustained glutathione peroxidase activation and enhanced osteoarthritis therapeutics

W Hu, X Yao, Y Li, J Li, J Zhang, Z Zou, F Kang… - Materials Today Bio, 2023 - Elsevier
Reactive oxygen burst in articular chondrocytes is a major contributor to osteoarthritis
progression. Although selenium is indispensable role in the antioxidant process, the narrow …

Nano‑selenium alleviates the pyroptosis of cardiovascular endothelial cells in chicken induced by decabromodiphenyl ether through ERS-TXNIP-NLRP3 pathway

Y Jiang, B Dong, X Jiao, J Shan, C Fang… - Science of The Total …, 2024 - Elsevier
Abstract Decabromodiphenyl ether (BDE-209) is one of the most widely used flame
retardants that can infect domestic and wildlife through contaminated feed. Nano‑selenium …

Self‐Assembly of Selenium‐Doped Carbon Quantum Dots as Antioxidants for Hepatic Ischemia‐Reperfusion Injury Management

B Bai, S Qi, K Yang, X Yu, R Jian, T Zhang, D Wang… - Small, 2023 - Wiley Online Library
Hepatic ischemia‐reperfusion injury (HIRI) is a critical complication after liver surgery that
negatively affects surgical outcomes of patients with the end‐stage liver‐related disease …

Black phosphorus nanosheets suppress oxidative damage of stem cells for improved neurological recovery

F He, Z Liu, J Xu, Y Xiong, X Zhang, J Qi, X Lin… - Chemical Engineering …, 2023 - Elsevier
Stem cell transplantation has wide application prospects in tissue injury recovery, especially
in neurological recovery. However, the low survival rate of stem cells after transplanted to …

Nanosystems for oxidative stress regulation in the anti-inflammatory therapy of acute kidney injury

Y Wang, H Jiang, L Zhang, P Yao, S Wang… - … in Bioengineering and …, 2023 - frontiersin.org
Acute kidney injury (AKI) is a clinical syndrome that results from a rapid decline in renal
structure or renal functional impairment with the main pathological feature of sublethal and …

Nephroprotective effects of selenium nanoparticles against sodium arsenite-induced damages

S Li, X Dong, L Xu, Z Wu - International Journal of Nanomedicine, 2023 - Taylor & Francis
Introduction The potential effects of selenium nanoparticles (SeNPs) administration on
arsenic exposure-mediated nephrotoxicity by alleviating fibrosis, inflammation, oxidative …