The interaction of antigen-presenting cells with free peptides or a denatured protein can give
rise to peptide–MHC class II complexes that are distinct from those generated after the …

Dedicated to the memory of Professors Henry G. Kunkel and Bruce Merrifield (Rockefeller
University, New York), who introduced us to the fascinating worlds of immunology and …

Glycoconjugate vaccines have provided enormous health benefits globally, but they have
been less successful in some populations at high risk for developing disease. To identify …

The OVA 323–339 epitope recognized by DO11. 10 (H-2 d) and OT-II (H-2 b) T cells was
investigated using amino-and carboxy-terminal truncations to locate the approximate ends …

T cell priming to exogenous antigens reflects regulated antigen processing in dendritic cells,
subsequent homing to lymph nodes, sustained interactions between T cells and antigen …

The targeting of natural tolerogenic liver sinusoidal endothelial cells (LSEC) by
nanoparticles (NPs), decorated with a stabilin receptor ligand, is capable of generating …

In nonobese diabetic (NOD) mice, two sets of autoreactive CD4+ T cells recognize the B: 9–
23 segment of the insulin B chain. One set, type A, recognizes insulin presented by antigen …

Cell-cell communication mediates immune responses to physiological stimuli at local and
systemic levels. Intercellular communication occurs via a direct contact between cells as well …

Immunodominance refers to the restricted antigen specificity of T cells detected in the
immune response after immunization with complex antigens. Despite the presence of many …

Nucleic-acid-based immune adjuvants have been extensively investigated for the design of
cancer vaccines. However, nucleic acids often require the assistance of a carrier system to …